Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL

Allogeneic chimeric antigen receptor T-cell (CART) therapies require multiple gene edits to be clinically tractable. Most allogeneic CARTs have been created using gene editing techniques that induce DNA double-stranded breaks (DSBs), resulting in unintended on-target editing outcomes with potentiall...

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Detalles Bibliográficos
Autores principales: Diorio, Caroline, Murray, Ryan, Naniong, Mark, Barrera, Luis, Camblin, Adam, Chukinas, John, Coholan, Lindsey, Edwards, Aaron, Fuller, Tori, Gonzales, Claudia, Grupp, Stephan A., Ladd, Alden, Le, Melissa, Messana, Angelica, Musenge, Faith, Newman, Haley, Poh, Yeh-Chuin, Poulin, Henry, Ryan, Theresa, Shraim, Rawan, Tasian, Sarah K., Vincent, Tiffaney, Young, Lauren, Zhang, Yingying, Ciaramella, Giuseppe, Gehrke, Jason, Teachey, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373016/
https://www.ncbi.nlm.nih.gov/pubmed/35560156
http://dx.doi.org/10.1182/blood.2022015825

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