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Spatial and temporal intracerebral hemorrhage patterns in Dutch-type hereditary cerebral amyloid angiopathy
AIM: To investigate whether there is a topographical and temporal pattern of index and recurrent intracerebral hemorrhages (ICH) in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) to increase our understanding on CAA-related ICH development. METHODS: We included patients with DNA confirmed...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373023/ https://www.ncbi.nlm.nih.gov/pubmed/34791949 http://dx.doi.org/10.1177/17474930211057022 |
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author | Voigt, Sabine Amlal, Siham Koemans, Emma A Rasing, Ingeborg van Etten, Ellis S van Zwet, Erik W van Buchem, Mark A Terwindt, Gisela M van Walderveen, Marianne AA Wermer, Marieke JH |
author_facet | Voigt, Sabine Amlal, Siham Koemans, Emma A Rasing, Ingeborg van Etten, Ellis S van Zwet, Erik W van Buchem, Mark A Terwindt, Gisela M van Walderveen, Marianne AA Wermer, Marieke JH |
author_sort | Voigt, Sabine |
collection | PubMed |
description | AIM: To investigate whether there is a topographical and temporal pattern of index and recurrent intracerebral hemorrhages (ICH) in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) to increase our understanding on CAA-related ICH development. METHODS: We included patients with DNA confirmed D-CAA or a history with ≥1 lobar ICH and ≥1 first-degree relative with D-CAA. Topographical pattern was studied by location (proportion frontal/parietal/temporal/occipital; infra/supratentorial and occurrence ratios relative to lobe volume) and volume of index and recurrent ICHs were determined on CT. Temporal pattern was examined by time between recurrent ICHs was retrieved from medical records. RESULTS: We included 72 patients with D-CAA (mean age at index ICH 55 years) with in total 214 ICH. The median follow-up time was 7 years (range 0.8 to 28 years). All ICH were lobar and supratentorial. The index ICH was most frequently located in the occipital lobe (34% vs. 22% in the other three lobes; with index ICH occurrence ratios relative to lobe volume of 1.9 for occipital, 1.0 for temporal, 1.2 for parietal, and 0.5 for frontal, p = 0.001). In 16/47 (34%) patients with multiple ICH, the second ICH was located in the same lobe as the index ICH. The median time-interval between subsequent ICH was #1-2 ICH 27 months, #2-3 ICH 14 months, and #3-4 ICH 7 months (p = 0.6) There was no difference in volume between index and recurrent ICHs. CONCLUSIONS: We found that index and recurrent ICHs in D-CAA have a preference for the occipital lobe and are least frequent in the frontal lobe, which adds to the existing knowledge of histopathological studies on amyloid load in CAA. Surprisingly, there was no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs. |
format | Online Article Text |
id | pubmed-9373023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-93730232022-08-13 Spatial and temporal intracerebral hemorrhage patterns in Dutch-type hereditary cerebral amyloid angiopathy Voigt, Sabine Amlal, Siham Koemans, Emma A Rasing, Ingeborg van Etten, Ellis S van Zwet, Erik W van Buchem, Mark A Terwindt, Gisela M van Walderveen, Marianne AA Wermer, Marieke JH Int J Stroke Research AIM: To investigate whether there is a topographical and temporal pattern of index and recurrent intracerebral hemorrhages (ICH) in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) to increase our understanding on CAA-related ICH development. METHODS: We included patients with DNA confirmed D-CAA or a history with ≥1 lobar ICH and ≥1 first-degree relative with D-CAA. Topographical pattern was studied by location (proportion frontal/parietal/temporal/occipital; infra/supratentorial and occurrence ratios relative to lobe volume) and volume of index and recurrent ICHs were determined on CT. Temporal pattern was examined by time between recurrent ICHs was retrieved from medical records. RESULTS: We included 72 patients with D-CAA (mean age at index ICH 55 years) with in total 214 ICH. The median follow-up time was 7 years (range 0.8 to 28 years). All ICH were lobar and supratentorial. The index ICH was most frequently located in the occipital lobe (34% vs. 22% in the other three lobes; with index ICH occurrence ratios relative to lobe volume of 1.9 for occipital, 1.0 for temporal, 1.2 for parietal, and 0.5 for frontal, p = 0.001). In 16/47 (34%) patients with multiple ICH, the second ICH was located in the same lobe as the index ICH. The median time-interval between subsequent ICH was #1-2 ICH 27 months, #2-3 ICH 14 months, and #3-4 ICH 7 months (p = 0.6) There was no difference in volume between index and recurrent ICHs. CONCLUSIONS: We found that index and recurrent ICHs in D-CAA have a preference for the occipital lobe and are least frequent in the frontal lobe, which adds to the existing knowledge of histopathological studies on amyloid load in CAA. Surprisingly, there was no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs. SAGE Publications 2021-11-18 2022-08 /pmc/articles/PMC9373023/ /pubmed/34791949 http://dx.doi.org/10.1177/17474930211057022 Text en © 2021 World Stroke Organization https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Voigt, Sabine Amlal, Siham Koemans, Emma A Rasing, Ingeborg van Etten, Ellis S van Zwet, Erik W van Buchem, Mark A Terwindt, Gisela M van Walderveen, Marianne AA Wermer, Marieke JH Spatial and temporal intracerebral hemorrhage patterns in Dutch-type hereditary cerebral amyloid angiopathy |
title | Spatial and temporal intracerebral hemorrhage patterns in Dutch-type
hereditary cerebral amyloid angiopathy |
title_full | Spatial and temporal intracerebral hemorrhage patterns in Dutch-type
hereditary cerebral amyloid angiopathy |
title_fullStr | Spatial and temporal intracerebral hemorrhage patterns in Dutch-type
hereditary cerebral amyloid angiopathy |
title_full_unstemmed | Spatial and temporal intracerebral hemorrhage patterns in Dutch-type
hereditary cerebral amyloid angiopathy |
title_short | Spatial and temporal intracerebral hemorrhage patterns in Dutch-type
hereditary cerebral amyloid angiopathy |
title_sort | spatial and temporal intracerebral hemorrhage patterns in dutch-type
hereditary cerebral amyloid angiopathy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373023/ https://www.ncbi.nlm.nih.gov/pubmed/34791949 http://dx.doi.org/10.1177/17474930211057022 |
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