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Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching

BACKGROUND: Neuraxial analgesia is widely used to relieve labor pain; its effects on long-term neurodevelopment of offspring remain unclear. This study was designed to investigate the influence of maternal neuraxial labor analgesia on offspring mental development. METHODS: This was a predefined seco...

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Autores principales: Deng, Chun-Mei, Ding, Ting, Liu, Zhi-Hua, He, Shu-Ting, Ma, Jia-Hui, Xu, Ming-Jun, Wang, Lei, Li, Ming, Liang, Wei-Lan, Li, Xue-Ying, Ma, Daqing, Wang, Dong-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373030/
https://www.ncbi.nlm.nih.gov/pubmed/35968440
http://dx.doi.org/10.3389/fpubh.2022.831538
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author Deng, Chun-Mei
Ding, Ting
Liu, Zhi-Hua
He, Shu-Ting
Ma, Jia-Hui
Xu, Ming-Jun
Wang, Lei
Li, Ming
Liang, Wei-Lan
Li, Xue-Ying
Ma, Daqing
Wang, Dong-Xin
author_facet Deng, Chun-Mei
Ding, Ting
Liu, Zhi-Hua
He, Shu-Ting
Ma, Jia-Hui
Xu, Ming-Jun
Wang, Lei
Li, Ming
Liang, Wei-Lan
Li, Xue-Ying
Ma, Daqing
Wang, Dong-Xin
author_sort Deng, Chun-Mei
collection PubMed
description BACKGROUND: Neuraxial analgesia is widely used to relieve labor pain; its effects on long-term neurodevelopment of offspring remain unclear. This study was designed to investigate the influence of maternal neuraxial labor analgesia on offspring mental development. METHODS: This was a predefined secondary analysis of a 2-year prospective longitudinal study. Nulliparous women with single-term cephalic pregnancy preparing for vaginal delivery self-selected neuraxial analgesia or not during labor. Mothers and their offspring were followed up 2 years later. children's mental development was assessed with the bayley scales of infant development. A multivariable logistic model was used to identify factors associated with below-average mental development (Mental Development Index <90). RESULTS: A Total of 508 pairs of mothers and children completed a 2-year follow-up. after propensity score matching, 387 pairs were included in the analysis. In both cohorts, the proportions with below-average mental development were slightly lower in children whose mothers received neuraxial labor analgesia, although not statistically significant [in the full cohort: 9.8 % (36/368) vs. 15.7% (22/140), P = 0.060; In the matched cohort: 8.3% (21/254) vs. 14.3% (19/133), P = 0.065]. A higher 2-year depression score (in the full cohort: Odds Ratio 1.15, 95% CI 1.08–1.22, P < 0.001; In the matched cohort: Odds Ratio 1.09, 95% CI 1.01–1.18, P = 0.037), but not neuraxial analgesia exposure, was associated with an increased risk of below-average mental development. CONCLUSIONS: Maternal depression at 2 years was associated with the risk of below-average mental development, whereas maternal exposure to neuraxial labor analgesia was not. CLINICAL TRIAL REGISTRATION: The study was registered with www.chictr.org.cn (ChiCTR-OCH-14004888) and ClinicalTrials.gov (NCT02823418).
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spelling pubmed-93730302022-08-13 Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching Deng, Chun-Mei Ding, Ting Liu, Zhi-Hua He, Shu-Ting Ma, Jia-Hui Xu, Ming-Jun Wang, Lei Li, Ming Liang, Wei-Lan Li, Xue-Ying Ma, Daqing Wang, Dong-Xin Front Public Health Public Health BACKGROUND: Neuraxial analgesia is widely used to relieve labor pain; its effects on long-term neurodevelopment of offspring remain unclear. This study was designed to investigate the influence of maternal neuraxial labor analgesia on offspring mental development. METHODS: This was a predefined secondary analysis of a 2-year prospective longitudinal study. Nulliparous women with single-term cephalic pregnancy preparing for vaginal delivery self-selected neuraxial analgesia or not during labor. Mothers and their offspring were followed up 2 years later. children's mental development was assessed with the bayley scales of infant development. A multivariable logistic model was used to identify factors associated with below-average mental development (Mental Development Index <90). RESULTS: A Total of 508 pairs of mothers and children completed a 2-year follow-up. after propensity score matching, 387 pairs were included in the analysis. In both cohorts, the proportions with below-average mental development were slightly lower in children whose mothers received neuraxial labor analgesia, although not statistically significant [in the full cohort: 9.8 % (36/368) vs. 15.7% (22/140), P = 0.060; In the matched cohort: 8.3% (21/254) vs. 14.3% (19/133), P = 0.065]. A higher 2-year depression score (in the full cohort: Odds Ratio 1.15, 95% CI 1.08–1.22, P < 0.001; In the matched cohort: Odds Ratio 1.09, 95% CI 1.01–1.18, P = 0.037), but not neuraxial analgesia exposure, was associated with an increased risk of below-average mental development. CONCLUSIONS: Maternal depression at 2 years was associated with the risk of below-average mental development, whereas maternal exposure to neuraxial labor analgesia was not. CLINICAL TRIAL REGISTRATION: The study was registered with www.chictr.org.cn (ChiCTR-OCH-14004888) and ClinicalTrials.gov (NCT02823418). Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9373030/ /pubmed/35968440 http://dx.doi.org/10.3389/fpubh.2022.831538 Text en Copyright © 2022 Deng, Ding, Liu, He, Ma, Xu, Wang, Li, Liang, Li, Ma and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Deng, Chun-Mei
Ding, Ting
Liu, Zhi-Hua
He, Shu-Ting
Ma, Jia-Hui
Xu, Ming-Jun
Wang, Lei
Li, Ming
Liang, Wei-Lan
Li, Xue-Ying
Ma, Daqing
Wang, Dong-Xin
Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching
title Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching
title_full Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching
title_fullStr Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching
title_full_unstemmed Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching
title_short Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching
title_sort impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: a longitudinal prospective cohort study with propensity score matching
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373030/
https://www.ncbi.nlm.nih.gov/pubmed/35968440
http://dx.doi.org/10.3389/fpubh.2022.831538
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