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Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography

PURPOSE: To establish normative data on the size, shape and vascular profile of the foveal avascular zone (FAZ) in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Certain diseases may alter FAZ appearance. Normative databases provide normal baseline values for comparison, thus impr...

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Autores principales: O'Shea, Susan M., O’Dwyer, Veronica M., Scanlon, Grainne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373196/
https://www.ncbi.nlm.nih.gov/pubmed/35001682
http://dx.doi.org/10.1177/11206721211073446
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author O'Shea, Susan M.
O’Dwyer, Veronica M.
Scanlon, Grainne
author_facet O'Shea, Susan M.
O’Dwyer, Veronica M.
Scanlon, Grainne
author_sort O'Shea, Susan M.
collection PubMed
description PURPOSE: To establish normative data on the size, shape and vascular profile of the foveal avascular zone (FAZ) in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Certain diseases may alter FAZ appearance. Normative databases provide normal baseline values for comparison, thus improving diagnostic ability. METHODS: One hundred and fifty-four subjects aged 18–35 years old were recruited. Superficial FAZ area, diameter, circularity, ganglion cell layer, central macular thickness (CMT), vascular perfusion and density were measured using the Cirrus 5000. Axial length was measured with the IOL Master and blood pressure was measured using the Omron sphygmomanometer. RESULTS: Mean FAZ area was 0.22 ± 0.07 mm(2), mean CMT was 263.08 ± 18.73μm. Both were larger in females than males (p = 0.022, p = 0.000). Mean vessel density and perfusion central were 14.11 ± 2.77 mm/mm(2) and 24.70 ± 4.96% respectively. Both were lower in females (p = 0.010, p = 0.019). Vessel density and perfusion inner correlated positively with minimum ganglion cell layer plus inner plexiform layer (GCL + IPL) thickness (p = 0.001, p = 0.019). CMT correlated positively with vessel density and perfusion central (p = 0.000 for both) and negatively with FAZ area (p = 0.000). CONCLUSIONS: This study provides normative data for FAZ appearance and vascularity for the first time in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Establishing machine and population specific normative data, particularly in relation to vessel density and perfusion is paramount to the early identification of ocular disease using Optical Coherence Tomography Angiography.
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spelling pubmed-93731962022-08-13 Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography O'Shea, Susan M. O’Dwyer, Veronica M. Scanlon, Grainne Eur J Ophthalmol Original Research Articles PURPOSE: To establish normative data on the size, shape and vascular profile of the foveal avascular zone (FAZ) in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Certain diseases may alter FAZ appearance. Normative databases provide normal baseline values for comparison, thus improving diagnostic ability. METHODS: One hundred and fifty-four subjects aged 18–35 years old were recruited. Superficial FAZ area, diameter, circularity, ganglion cell layer, central macular thickness (CMT), vascular perfusion and density were measured using the Cirrus 5000. Axial length was measured with the IOL Master and blood pressure was measured using the Omron sphygmomanometer. RESULTS: Mean FAZ area was 0.22 ± 0.07 mm(2), mean CMT was 263.08 ± 18.73μm. Both were larger in females than males (p = 0.022, p = 0.000). Mean vessel density and perfusion central were 14.11 ± 2.77 mm/mm(2) and 24.70 ± 4.96% respectively. Both were lower in females (p = 0.010, p = 0.019). Vessel density and perfusion inner correlated positively with minimum ganglion cell layer plus inner plexiform layer (GCL + IPL) thickness (p = 0.001, p = 0.019). CMT correlated positively with vessel density and perfusion central (p = 0.000 for both) and negatively with FAZ area (p = 0.000). CONCLUSIONS: This study provides normative data for FAZ appearance and vascularity for the first time in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Establishing machine and population specific normative data, particularly in relation to vessel density and perfusion is paramount to the early identification of ocular disease using Optical Coherence Tomography Angiography. SAGE Publications 2022-01-10 2022-09 /pmc/articles/PMC9373196/ /pubmed/35001682 http://dx.doi.org/10.1177/11206721211073446 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Articles
O'Shea, Susan M.
O’Dwyer, Veronica M.
Scanlon, Grainne
Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography
title Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography
title_full Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography
title_fullStr Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography
title_full_unstemmed Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography
title_short Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography
title_sort normative data on the foveal avascular zone in a young healthy irish population using optical coherence tomography angiography
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373196/
https://www.ncbi.nlm.nih.gov/pubmed/35001682
http://dx.doi.org/10.1177/11206721211073446
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