Cargando…

The effect of alpha-2A adrenergic receptor (ADRA2A) genetic polymorphisms on the depth of sedation of dexmedetomidine: a genetic observational pilot study

BACKGROUND: The genetic polymorphisms of the alpha-2A adrenergic receptor (ADRA2A), which plays a significant role in sedation, anxiety relief, and antinociception, particularly in dexmedetomidine, may differ in the degree of sedation. This study aimed to investigate the effect of the genetic polymo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Yoon Ji, Park, Kyu Hee, Park, Ju Yeon, Min, Won Kee, Lee, Yoon Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373641/ https://www.ncbi.nlm.nih.gov/pubmed/33915198 http://dx.doi.org/10.1016/j.bjane.2021.04.005

Ejemplares similares

A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients
por: Gallaway, Katherine A., et al.
Publicado: (2022)

Alpha2 Adrenergic Modulation of Spike-Wave Epilepsy: Experimental Study of Pro-Epileptic and Sedative Effects of Dexmedetomidine
por: Sitnikova, Evgenia, et al.
Publicado: (2023)

Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment
por: Brocos-Mosquera, Iria, et al.
Publicado: (2021)

Effect of ADRA2A gene polymorphisms on the anesthetic and analgesic effects of dexmedetomidine in Chinese Han women with cesarean section
por: Fu, Zhimei, et al.
Publicado: (2020)

Neuroprotective role of dexmedetomidine pretreatment in cerebral ischemia injury via ADRA2A-mediated phosphorylation of ERK1/2 in adult rats
por: Shi, Yanyan, et al.
Publicado: (2018)

ADRA2A is involved in neuro-endocrine regulation of bone resorption
por: Mlakar, Vid, et al.
Publicado: (2015)

ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon
por: Hartmann, Sylvia, et al.
Publicado: (2023)

Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation
por: Ki, Seunghee, et al.
Publicado: (2022)

Dexmedetomidine combined with midazolam vs. dexmedetomidine alone for sedation during spinal anesthesia
por: Yoon, Douk-Keun, et al.
Publicado: (2016)

Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients With Delayed Extubation After Craniotomy: A Randomized Controlled Trial
por: Zhao, Li-Hong, et al.
Publicado: (2017)

Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α(2)-adrenergic receptor competitive antagonist in combination with caffeine
por: Xie, Zheng, et al.
Publicado: (2023)

Dexmedetomidine sedation in ICU
por: Yu, Soo-Bong
Publicado: (2012)

Association Between SLC6A4 Serotonin Transporter Gene Lainked Polymorphic Region and ADRA2A −1291C>G and Irritable Bowel Syndrome in Korea
por: Choi, Yoon Jin, et al.
Publicado: (2014)

Dexmedetomidine versus midazolam for conscious sedation in endoscopic retrograde cholangiopancreatography: An open-label randomised controlled trial
por: Sethi, Priyanka, et al.
Publicado: (2014)

Impact of Nonselective and Selective α−1 Adrenergic Blockers on the Sedative Efficacy of Dexmedetomidine in Urologic Surgery: A Prospective, Observational Study
por: Baik, Jiseok, et al.
Publicado: (2023)

GENETIC VARIATION IN THE ALPHA(1B) - ADRENERGIC RECEPTOR AND VASCULAR RESPONSE
por: Adefurin, Abiodun, et al.
Publicado: (2016)

The prognostic value of ADRA1 subfamily genes in gastric carcinoma
por: Wang, Tingan, et al.
Publicado: (2019)

Dexmedetomidine for sedation in the medical ICU
por: Venn, RM, et al.
Publicado: (2000)

Comparative study between dexmedetomidine and fentanyl for sedation during mechanical ventilation in post-operative paediatric cardiac surgical patients
por: Prasad, SR, et al.
Publicado: (2012)

The effect of dexmedetomidine infusion on propofol requirement for maintenance of optimum depth of anaesthesia during elective spine surgery
por: Sen, Suvadeep, et al.
Publicado: (2013)

Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats
por: Savolainen, Katja, et al.
Publicado: (2018)

Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory
por: Fairfield, Beth, et al.
Publicado: (2019)

Changes in electroencephalographic power and bicoherence spectra according to depth of dexmedetomidine sedation in patients undergoing spinal anesthesia
por: Seo, Kwon Hui, et al.
Publicado: (2021)

Clinical significance of expression levels of serum ADRA1A in hysterocarcinoma patients
por: Peng, Lin, et al.
Publicado: (2018)

Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation
por: Ma, Ying, et al.
Publicado: (2019)

Dexmedetomidine for sedation of patients undergoing elective surgery under regional anesthesia
por: Song, Jia, et al.
Publicado: (2013)

Intranasal dexmedetomidine and intravenous ketamine for procedural sedation in a child with alpha-mannosidosis: a magic bullet?
por: Trevisan, Matteo, et al.
Publicado: (2019)

Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats
por: Park, Je Hoon, et al.
Publicado: (2017)

Optimal dose of dexmedetomidine for sedation during spinal anesthesia
por: Ok, Hwoe-Gyeong, et al.
Publicado: (2013)

Additional sedative drugs to light sedation with dexmedetomidine is risk for delirium
por: Sakuraya, M, et al.
Publicado: (2015)

Dexmedetomidine hydrochloride as a long-term sedative
por: Kunisawa, Takayuki
Publicado: (2011)

Effects of low dose dexmedetomidine infusion on haemodynamic stress response, sedation and post-operative analgesia requirement in patients undergoing laparoscopic cholecystectomy
por: Manne, Gourishankar Reddy, et al.
Publicado: (2014)

Association of Dexmedetomidine With New-Onset Atrial Fibrillation in Patients With Critical Illness
por: Song, Myung Jin, et al.
Publicado: (2023)

Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population
por: Kim, Yun Sung, et al.
Publicado: (2015)

Dexmedetomidine for Sedation during Withdrawal of Support
por: O’Hara, Chris, et al.
Publicado: (2015)

Sedation with dexmedetomidine in the intensive care setting
por: Gerlach, Anthony T, et al.
Publicado: (2011)

Role of dexmedetomidine in pediatric dental sedation
por: Mohite, Vedangi, et al.
Publicado: (2019)

Sedative and Immunosuppressive Effects of Dexmedetomidine in Transplantation
por: Lee, Chen-Fang, et al.
Publicado: (2021)

Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individuals
por: Amorim Belo Nunes, Rafael, et al.
Publicado: (2016)

The Richmond agitation–sedation scale and bispectral index during dexmedetomidine sedation
por: Turkmen, A, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_iancri48m0qpbeictpg9db7p7e