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Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial
BACKGROUND: The role of intravenous lidocaine infusion in endoscopic surgery has been previously evaluated for pain relief and recovery. Recently, it has been shown to reduce postoperative pain and opioid in patients undergoing endoscopic submucosal dissection. Similar to endoscopic submucosal disse...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373697/ https://www.ncbi.nlm.nih.gov/pubmed/34229861 http://dx.doi.org/10.1016/j.bjane.2021.02.015 |
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author | Peng, Xuan Zhao, Yuzi Xiao, Yeda Zhan, Liying Wang, Huaxin |
author_facet | Peng, Xuan Zhao, Yuzi Xiao, Yeda Zhan, Liying Wang, Huaxin |
author_sort | Peng, Xuan |
collection | PubMed |
description | BACKGROUND: The role of intravenous lidocaine infusion in endoscopic surgery has been previously evaluated for pain relief and recovery. Recently, it has been shown to reduce postoperative pain and opioid in patients undergoing endoscopic submucosal dissection. Similar to endoscopic submucosal dissection, operative hysteroscopy is also an endoscopic surgical procedure within natural lumens. The present study was a randomized clinical trial in which we evaluated whether intravenous lidocaine infusion would reduce postoperative pain in patients undergoing hysteroscopic surgery. OBJECTIVE: To evaluate whether intravenous lidocaine infusion could reduce postoperative pain in patients undergoing operative hysteroscopy. METHODS: Eighty-five patients scheduled to undergo elective hysteroscopy were randomized to receive either an intravenous bolus of lidocaine 1.5 mg.kg(-1) over 3 minutes, followed by continuous infusion at a rate of 2 mg.kg(-1). h(-1) during surgery, or 0.9% normal saline solution at the same rate. The primary outcome was to evaluate postoperative pain by Visual Analog Scale (VAS). Secondary outcomes included remifentanil and propofol consumption. RESULTS: In the lidocaine group, the VAS was significantly lower at 0.5 hour (p = 0.008) and 4 hours (p = 0.020). Patients in the lidocaine group required less remifentanil than patients in the control group (p < 0.001). However, there was no difference between the two groups in the propofol consumption. The incidence of throat pain was significantly lower in the lidocaine group (p = 0.019). No adverse events associated with lidocaine infusion were discovered. CONCLUSION: Intravenous lidocaine infusion as an adjuvant reduces short-term postoperative pain in patients undergoing operative hysteroscopy. |
format | Online Article Text |
id | pubmed-9373697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93736972022-08-15 Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial Peng, Xuan Zhao, Yuzi Xiao, Yeda Zhan, Liying Wang, Huaxin Braz J Anesthesiol Clinical Research BACKGROUND: The role of intravenous lidocaine infusion in endoscopic surgery has been previously evaluated for pain relief and recovery. Recently, it has been shown to reduce postoperative pain and opioid in patients undergoing endoscopic submucosal dissection. Similar to endoscopic submucosal dissection, operative hysteroscopy is also an endoscopic surgical procedure within natural lumens. The present study was a randomized clinical trial in which we evaluated whether intravenous lidocaine infusion would reduce postoperative pain in patients undergoing hysteroscopic surgery. OBJECTIVE: To evaluate whether intravenous lidocaine infusion could reduce postoperative pain in patients undergoing operative hysteroscopy. METHODS: Eighty-five patients scheduled to undergo elective hysteroscopy were randomized to receive either an intravenous bolus of lidocaine 1.5 mg.kg(-1) over 3 minutes, followed by continuous infusion at a rate of 2 mg.kg(-1). h(-1) during surgery, or 0.9% normal saline solution at the same rate. The primary outcome was to evaluate postoperative pain by Visual Analog Scale (VAS). Secondary outcomes included remifentanil and propofol consumption. RESULTS: In the lidocaine group, the VAS was significantly lower at 0.5 hour (p = 0.008) and 4 hours (p = 0.020). Patients in the lidocaine group required less remifentanil than patients in the control group (p < 0.001). However, there was no difference between the two groups in the propofol consumption. The incidence of throat pain was significantly lower in the lidocaine group (p = 0.019). No adverse events associated with lidocaine infusion were discovered. CONCLUSION: Intravenous lidocaine infusion as an adjuvant reduces short-term postoperative pain in patients undergoing operative hysteroscopy. Elsevier 2021-02-06 /pmc/articles/PMC9373697/ /pubmed/34229861 http://dx.doi.org/10.1016/j.bjane.2021.02.015 Text en © 2021 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical Research Peng, Xuan Zhao, Yuzi Xiao, Yeda Zhan, Liying Wang, Huaxin Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial |
title | Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial |
title_full | Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial |
title_fullStr | Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial |
title_full_unstemmed | Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial |
title_short | Effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial |
title_sort | effect of intravenous lidocaine on short-term pain after hysteroscopy: a randomized clinical trial |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373697/ https://www.ncbi.nlm.nih.gov/pubmed/34229861 http://dx.doi.org/10.1016/j.bjane.2021.02.015 |
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