Cargando…

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis

Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-wide. Accumulating evidence attests to the important roles of the immune system in OA pathogenesis. Understanding the role of various immune cells in joint degeneration or joint repair after injury is vital...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sebastian, Aimy, Hum, Nicholas R., McCool, Jillian L., Wilson, Stephen P., Murugesh, Deepa K., Martin, Kelly A., Rios-Arce, Naiomy Deliz, Amiri, Beheshta, Christiansen, Blaine A., Loots, Gabriela G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373730/ https://www.ncbi.nlm.nih.gov/pubmed/35967299 http://dx.doi.org/10.3389/fimmu.2022.938075

Ejemplares similares

Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice
por: Sebastian, Aimy, et al.
Publicado: (2020)

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes
por: Sebastian, Aimy, et al.
Publicado: (2021)

LPS‐Induced Inflammation Prior to Injury Exacerbates the Development of Post‐Traumatic Osteoarthritis in Mice
por: Mendez, Melanie E, et al.
Publicado: (2020)

Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis
por: Rios‐Arce, Naiomy D, et al.
Publicado: (2022)

Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice
por: Mendez, Melanie E., et al.
Publicado: (2020)

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis
por: Chang, Jiun C., et al.
Publicado: (2016)

Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data
por: Rios‐Arce, Naiomy D., et al.
Publicado: (2022)

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression
por: Sebastian, Aimy, et al.
Publicado: (2018)

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury
por: Chang, Jiun C, et al.
Publicado: (2018)

Antibiotic Treatment Prior to Injury Abrogates the Detrimental Effects of LPS in STR/ort Mice Susceptible to Osteoarthritis Development
por: Mendez, Melanie E, et al.
Publicado: (2023)

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts
por: Sebastian, Aimy, et al.
Publicado: (2017)

IL-17A Increases Doxorubicin Efficacy in Triple Negative Breast Cancer
por: Hum, Nicholas R., et al.
Publicado: (2022)

Loss of Cadherin-11 in pancreatic ductal adenocarcinoma alters tumor-immune microenvironment
por: Sebastian, Aimy, et al.
Publicado: (2023)

Cytokine and hormonal regulation of bone marrow immune cell Wnt10b expression
por: Collins, Fraser L., et al.
Publicado: (2017)

SOST Inhibits Prostate Cancer Invasion
por: Hudson, Bryan D., et al.
Publicado: (2015)

Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer
por: Sebastian, Aimy, et al.
Publicado: (2015)

Degradation‐Resistant Hypoxia Inducible Factor‐2α in Murine Osteocytes Promotes a High Bone Mass Phenotype
por: Mendoza, Sarah V., et al.
Publicado: (2023)

Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice
por: Donham, Cristine, et al.
Publicado: (2021)

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner()
por: Collette, Nicole M., et al.
Publicado: (2013)

Host tracheal and intestinal microbiomes inhibit Coccidioides growth in vitro
por: Tejeda-Garibay, Susana, et al.
Publicado: (2023)

Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice
por: Malfatti, Michael A., et al.
Publicado: (2020)

Beneficial effects of Lactobacillus reuteri 6475 on bone density in male mice is dependent on lymphocytes
por: Collins, Fraser L., et al.
Publicado: (2019)

Global Gene Expression Analysis of Murine Limb Development
por: Taher, Leila, et al.
Publicado: (2011)

4260 Hollow, Degradable poly(N-Isopropylacrylamide) Derived Nanoparticles for the Delivery of Anti-Inflammatory Peptides for the Treatment and Prevention of Post-Traumatic Osteoarthritis
por: Deloney, Marcus A, et al.
Publicado: (2020)

Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice
por: Khorasani, Mohammad S, et al.
Publicado: (2015)

MAVS mediates a protective immune response in the brain to Rift Valley fever virus
por: Hum, Nicholas R., et al.
Publicado: (2022)

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer
por: Sebastian, Aimy, et al.
Publicado: (2020)

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice
por: Martin, Kelly A., et al.
Publicado: (2019)

Dose-dependent consequences of sub-chronic fentanyl exposure on neuron and glial co-cultures
por: Lam, Doris, et al.
Publicado: (2022)

Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening
por: Griffin, Katherine H., et al.
Publicado: (2023)

Reaching a global online audience
por: McCool, Matthew
Publicado: (2007)

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables
por: Christiansen, Blaine A., et al.
Publicado: (2015)

Using the Weibull distribution: reliability, modeling and inference
por: McCool, John I
Publicado: (2012)

Response to the Letter to the Editor for “Management of Osteoarthritis with Avocado/Soybean Unsaponifiables”
por: Christiansen, Blaine A., et al.
Publicado: (2016)

Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo
por: Hum, Nicholas R., et al.
Publicado: (2020)

Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors
por: Farroni, Jeffrey S, et al.
Publicado: (2004)

Metaprogramming GPUs with Sh
por: McCool, Michael, et al.
Publicado: (2004)

Salmonella infantis ulcerative keratitis in a dog
por: Routh, Brayden L., et al.
Publicado: (2022)

65993 Peptide Conjugated Hollow, Degradable Nanoparticles Bind to Exposed Hyaluronic Acid for the Prevention and Treatment of Osteoarthritis
por: Deloney, Marcus, et al.
Publicado: (2021)

The Metabolic Landscape in Osteoarthritis
por: Wu, Xiaoxin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qj9bptjsp6radn1290q0d4tjni