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Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)

Genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 was developed by crossing to combine five single events: MON 89034, 1507, MIR162, NK603 and DAS‐40278‐9. The GMO Panel previously assessed the five single maize events and 16 of the subcombinations and did not identify safety...

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Autores principales: Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Naegeli, Hanspeter, Moreno, Francisco Javier, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Dumont, Antonio Fernandez, Federici, Silvia, Gennaro, Andrea, Gomez Ruiz, Jose Angel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lanzoni, Anna, Lenzi, Paolo, Lewandowska, Aleksandra, Neri, Franco Maria, Paraskevopoulos, Konstantinos, Raffaello, Tommaso, Streissl, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373840/
https://www.ncbi.nlm.nih.gov/pubmed/35978615
http://dx.doi.org/10.2903/j.efsa.2022.7451
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author Mullins, Ewen
Bresson, Jean‐Louis
Dalmay, Tamas
Dewhurst, Ian Crawford
Epstein, Michelle M
Firbank, Leslie George
Guerche, Philippe
Hejatko, Jan
Naegeli, Hanspeter
Moreno, Francisco Javier
Nogué, Fabien
Rostoks, Nils
Sánchez Serrano, Jose Juan
Savoini, Giovanni
Veromann, Eve
Veronesi, Fabio
Ardizzone, Michele
De Sanctis, Giacomo
Dumont, Antonio Fernandez
Federici, Silvia
Gennaro, Andrea
Gomez Ruiz, Jose Angel
Goumperis, Tilemachos
Kagkli, Dafni Maria
Lanzoni, Anna
Lenzi, Paolo
Lewandowska, Aleksandra
Neri, Franco Maria
Paraskevopoulos, Konstantinos
Raffaello, Tommaso
Streissl, Franz
author_facet Mullins, Ewen
Bresson, Jean‐Louis
Dalmay, Tamas
Dewhurst, Ian Crawford
Epstein, Michelle M
Firbank, Leslie George
Guerche, Philippe
Hejatko, Jan
Naegeli, Hanspeter
Moreno, Francisco Javier
Nogué, Fabien
Rostoks, Nils
Sánchez Serrano, Jose Juan
Savoini, Giovanni
Veromann, Eve
Veronesi, Fabio
Ardizzone, Michele
De Sanctis, Giacomo
Dumont, Antonio Fernandez
Federici, Silvia
Gennaro, Andrea
Gomez Ruiz, Jose Angel
Goumperis, Tilemachos
Kagkli, Dafni Maria
Lanzoni, Anna
Lenzi, Paolo
Lewandowska, Aleksandra
Neri, Franco Maria
Paraskevopoulos, Konstantinos
Raffaello, Tommaso
Streissl, Franz
collection PubMed
description Genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 was developed by crossing to combine five single events: MON 89034, 1507, MIR162, NK603 and DAS‐40278‐9. The GMO Panel previously assessed the five single maize events and 16 of the subcombinations and did not identify safety concerns. No new data on the single maize events or the assessed subcombinations were identified that could lead to the modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in the five‐event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that five‐event stack maize, as described in this application, is as safe as the non‐GM comparator and non‐GM maize varieties tested. In the case of accidental release of viable five‐event stack maize grains into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in nine of the maize subcombinations not previously assessed and concludes that these are expected to be as safe as the single events, the previously assessed subcombinations and the five‐event stack maize. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9. Post‐market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the five‐event stack maize and its subcombinations are as safe as its non‐GM comparator and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment.
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spelling pubmed-93738402022-08-16 Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151) Mullins, Ewen Bresson, Jean‐Louis Dalmay, Tamas Dewhurst, Ian Crawford Epstein, Michelle M Firbank, Leslie George Guerche, Philippe Hejatko, Jan Naegeli, Hanspeter Moreno, Francisco Javier Nogué, Fabien Rostoks, Nils Sánchez Serrano, Jose Juan Savoini, Giovanni Veromann, Eve Veronesi, Fabio Ardizzone, Michele De Sanctis, Giacomo Dumont, Antonio Fernandez Federici, Silvia Gennaro, Andrea Gomez Ruiz, Jose Angel Goumperis, Tilemachos Kagkli, Dafni Maria Lanzoni, Anna Lenzi, Paolo Lewandowska, Aleksandra Neri, Franco Maria Paraskevopoulos, Konstantinos Raffaello, Tommaso Streissl, Franz EFSA J Scientific Opinion Genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 was developed by crossing to combine five single events: MON 89034, 1507, MIR162, NK603 and DAS‐40278‐9. The GMO Panel previously assessed the five single maize events and 16 of the subcombinations and did not identify safety concerns. No new data on the single maize events or the assessed subcombinations were identified that could lead to the modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in the five‐event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that five‐event stack maize, as described in this application, is as safe as the non‐GM comparator and non‐GM maize varieties tested. In the case of accidental release of viable five‐event stack maize grains into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in nine of the maize subcombinations not previously assessed and concludes that these are expected to be as safe as the single events, the previously assessed subcombinations and the five‐event stack maize. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9. Post‐market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the five‐event stack maize and its subcombinations are as safe as its non‐GM comparator and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment. John Wiley and Sons Inc. 2022-08-12 /pmc/articles/PMC9373840/ /pubmed/35978615 http://dx.doi.org/10.2903/j.efsa.2022.7451 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Mullins, Ewen
Bresson, Jean‐Louis
Dalmay, Tamas
Dewhurst, Ian Crawford
Epstein, Michelle M
Firbank, Leslie George
Guerche, Philippe
Hejatko, Jan
Naegeli, Hanspeter
Moreno, Francisco Javier
Nogué, Fabien
Rostoks, Nils
Sánchez Serrano, Jose Juan
Savoini, Giovanni
Veromann, Eve
Veronesi, Fabio
Ardizzone, Michele
De Sanctis, Giacomo
Dumont, Antonio Fernandez
Federici, Silvia
Gennaro, Andrea
Gomez Ruiz, Jose Angel
Goumperis, Tilemachos
Kagkli, Dafni Maria
Lanzoni, Anna
Lenzi, Paolo
Lewandowska, Aleksandra
Neri, Franco Maria
Paraskevopoulos, Konstantinos
Raffaello, Tommaso
Streissl, Franz
Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)
title Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)
title_full Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)
title_fullStr Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)
title_full_unstemmed Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)
title_short Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)
title_sort assessment of genetically modified maize mon 89034 × 1507 × mir162 × nk603 × das‐40278‐9 for food and feed uses, under regulation (ec) no 1829/2003 (application efsa‐gmo‐nl‐2018‐151)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373840/
https://www.ncbi.nlm.nih.gov/pubmed/35978615
http://dx.doi.org/10.2903/j.efsa.2022.7451
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