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A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
PURPOSE: Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro-imaging findings and determining local extent are essential for early...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373869/ https://www.ncbi.nlm.nih.gov/pubmed/35979155 http://dx.doi.org/10.5114/pjr.2022.118107 |
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author | Orman, Gunes Huisman, Thierry A.G.M. |
author_facet | Orman, Gunes Huisman, Thierry A.G.M. |
author_sort | Orman, Gunes |
collection | PubMed |
description | PURPOSE: Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro-imaging findings and determining local extent are essential for early diagnosis and therapy guidance. The purpose of this study is to evaluate and to provide a detailed list of neuroimaging features of RB to improve the diagnostic work-up of children with RB. MATERIAL AND METHODS: Retrospective review was performed among children with confirmed RB diagnosis. MRI features were identified to evaluate: 1) growth pattern; 2) intraocular extension; 3) extraocular extension; 4) central nervous system disease; 5) conventional MRI characteristics of the RB lesions; and 6) DWI and ADC characteristics. These features were compared between unilateral and bilateral RB lesions. RESULTS: Twenty-four children (male/female: 18/6) were included in this study. The mean age at the time of diagnosis was 14.7 (11.4) months. In total, 34 RB lesions (bilateral = 18) were evaluated for the study. The most common features on MRI were: 1) endophytic RB lesion (50%); 2) subretinal haemorrhage (38%); 3) scleral involvement (3%); 4) leptomeningeal disease (12%); 5) contrast enhancement (97%); and 6) restricted diffusion (88%). The mean ADC value was 0.64 (0.15) × 10(-3) mm(2)/s. Choroidal invasion (p = 0.05) and scleral involvement (p = 0.04) were significantly higher for bilateral RB lesions. CONCLUSIONS: Contrast enhancement and restricted diffusion are the most common neuroimaging features of RB. Choroidal invasion and scleral involvement are more frequently seen in bilateral disease. |
format | Online Article Text |
id | pubmed-9373869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-93738692022-08-16 A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features Orman, Gunes Huisman, Thierry A.G.M. Pol J Radiol Original Paper PURPOSE: Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro-imaging findings and determining local extent are essential for early diagnosis and therapy guidance. The purpose of this study is to evaluate and to provide a detailed list of neuroimaging features of RB to improve the diagnostic work-up of children with RB. MATERIAL AND METHODS: Retrospective review was performed among children with confirmed RB diagnosis. MRI features were identified to evaluate: 1) growth pattern; 2) intraocular extension; 3) extraocular extension; 4) central nervous system disease; 5) conventional MRI characteristics of the RB lesions; and 6) DWI and ADC characteristics. These features were compared between unilateral and bilateral RB lesions. RESULTS: Twenty-four children (male/female: 18/6) were included in this study. The mean age at the time of diagnosis was 14.7 (11.4) months. In total, 34 RB lesions (bilateral = 18) were evaluated for the study. The most common features on MRI were: 1) endophytic RB lesion (50%); 2) subretinal haemorrhage (38%); 3) scleral involvement (3%); 4) leptomeningeal disease (12%); 5) contrast enhancement (97%); and 6) restricted diffusion (88%). The mean ADC value was 0.64 (0.15) × 10(-3) mm(2)/s. Choroidal invasion (p = 0.05) and scleral involvement (p = 0.04) were significantly higher for bilateral RB lesions. CONCLUSIONS: Contrast enhancement and restricted diffusion are the most common neuroimaging features of RB. Choroidal invasion and scleral involvement are more frequently seen in bilateral disease. Termedia Publishing House 2022-07-04 /pmc/articles/PMC9373869/ /pubmed/35979155 http://dx.doi.org/10.5114/pjr.2022.118107 Text en Copyright © Polish Medical Society of Radiology 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Paper Orman, Gunes Huisman, Thierry A.G.M. A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features |
title | A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features |
title_full | A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features |
title_fullStr | A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features |
title_full_unstemmed | A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features |
title_short | A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features |
title_sort | descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373869/ https://www.ncbi.nlm.nih.gov/pubmed/35979155 http://dx.doi.org/10.5114/pjr.2022.118107 |
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