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A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features

PURPOSE: Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro-imaging findings and determining local extent are essential for early...

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Autores principales: Orman, Gunes, Huisman, Thierry A.G.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373869/
https://www.ncbi.nlm.nih.gov/pubmed/35979155
http://dx.doi.org/10.5114/pjr.2022.118107
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author Orman, Gunes
Huisman, Thierry A.G.M.
author_facet Orman, Gunes
Huisman, Thierry A.G.M.
author_sort Orman, Gunes
collection PubMed
description PURPOSE: Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro-imaging findings and determining local extent are essential for early diagnosis and therapy guidance. The purpose of this study is to evaluate and to provide a detailed list of neuroimaging features of RB to improve the diagnostic work-up of children with RB. MATERIAL AND METHODS: Retrospective review was performed among children with confirmed RB diagnosis. MRI features were identified to evaluate: 1) growth pattern; 2) intraocular extension; 3) extraocular extension; 4) central nervous system disease; 5) conventional MRI characteristics of the RB lesions; and 6) DWI and ADC characteristics. These features were compared between unilateral and bilateral RB lesions. RESULTS: Twenty-four children (male/female: 18/6) were included in this study. The mean age at the time of diagnosis was 14.7 (11.4) months. In total, 34 RB lesions (bilateral = 18) were evaluated for the study. The most common features on MRI were: 1) endophytic RB lesion (50%); 2) subretinal haemorrhage (38%); 3) scleral involvement (3%); 4) leptomeningeal disease (12%); 5) contrast enhancement (97%); and 6) restricted diffusion (88%). The mean ADC value was 0.64 (0.15) × 10(-3) mm(2)/s. Choroidal invasion (p = 0.05) and scleral involvement (p = 0.04) were significantly higher for bilateral RB lesions. CONCLUSIONS: Contrast enhancement and restricted diffusion are the most common neuroimaging features of RB. Choroidal invasion and scleral involvement are more frequently seen in bilateral disease.
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spelling pubmed-93738692022-08-16 A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features Orman, Gunes Huisman, Thierry A.G.M. Pol J Radiol Original Paper PURPOSE: Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro-imaging findings and determining local extent are essential for early diagnosis and therapy guidance. The purpose of this study is to evaluate and to provide a detailed list of neuroimaging features of RB to improve the diagnostic work-up of children with RB. MATERIAL AND METHODS: Retrospective review was performed among children with confirmed RB diagnosis. MRI features were identified to evaluate: 1) growth pattern; 2) intraocular extension; 3) extraocular extension; 4) central nervous system disease; 5) conventional MRI characteristics of the RB lesions; and 6) DWI and ADC characteristics. These features were compared between unilateral and bilateral RB lesions. RESULTS: Twenty-four children (male/female: 18/6) were included in this study. The mean age at the time of diagnosis was 14.7 (11.4) months. In total, 34 RB lesions (bilateral = 18) were evaluated for the study. The most common features on MRI were: 1) endophytic RB lesion (50%); 2) subretinal haemorrhage (38%); 3) scleral involvement (3%); 4) leptomeningeal disease (12%); 5) contrast enhancement (97%); and 6) restricted diffusion (88%). The mean ADC value was 0.64 (0.15) × 10(-3) mm(2)/s. Choroidal invasion (p = 0.05) and scleral involvement (p = 0.04) were significantly higher for bilateral RB lesions. CONCLUSIONS: Contrast enhancement and restricted diffusion are the most common neuroimaging features of RB. Choroidal invasion and scleral involvement are more frequently seen in bilateral disease. Termedia Publishing House 2022-07-04 /pmc/articles/PMC9373869/ /pubmed/35979155 http://dx.doi.org/10.5114/pjr.2022.118107 Text en Copyright © Polish Medical Society of Radiology 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Paper
Orman, Gunes
Huisman, Thierry A.G.M.
A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
title A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
title_full A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
title_fullStr A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
title_full_unstemmed A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
title_short A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
title_sort descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373869/
https://www.ncbi.nlm.nih.gov/pubmed/35979155
http://dx.doi.org/10.5114/pjr.2022.118107
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