Cargando…

TRP channels and monoterpenes: Past and current leads on analgesic properties

The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloi...

Descripción completa

Detalles Bibliográficos
Autores principales: Petitjean, Hugues, Héberlé, Eléa, Hilfiger, Louis, Łapieś, Olga, Rodrigue, Guillaume, Charlet, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373873/
https://www.ncbi.nlm.nih.gov/pubmed/35966017
http://dx.doi.org/10.3389/fnmol.2022.945450
_version_ 1784767677917560832
author Petitjean, Hugues
Héberlé, Eléa
Hilfiger, Louis
Łapieś, Olga
Rodrigue, Guillaume
Charlet, Alexandre
author_facet Petitjean, Hugues
Héberlé, Eléa
Hilfiger, Louis
Łapieś, Olga
Rodrigue, Guillaume
Charlet, Alexandre
author_sort Petitjean, Hugues
collection PubMed
description The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity reactions. Monoterpenes, among which pulegone and menthol, a major class of phytocompounds present in essential oils of medicinal plants, are known modulators of those TRP channels activity. In the present review, we correlate the monoterpene content of plants with their historical therapeutic properties. We then describe how monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. Finally, we discuss the importance and the potential of characterizing new plant extracts and reassessing studied plant extracts for the development of ethnopharmacology-based innovative treatments for chronic pain. This review suggests that monoterpene solutions, based on composition from traditional healing herbs, offer an interesting avenue for the development of new phytotherapeutic treatments to alleviate chronic inflammatory pain conditions.
format Online
Article
Text
id pubmed-9373873
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93738732022-08-13 TRP channels and monoterpenes: Past and current leads on analgesic properties Petitjean, Hugues Héberlé, Eléa Hilfiger, Louis Łapieś, Olga Rodrigue, Guillaume Charlet, Alexandre Front Mol Neurosci Molecular Neuroscience The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity reactions. Monoterpenes, among which pulegone and menthol, a major class of phytocompounds present in essential oils of medicinal plants, are known modulators of those TRP channels activity. In the present review, we correlate the monoterpene content of plants with their historical therapeutic properties. We then describe how monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. Finally, we discuss the importance and the potential of characterizing new plant extracts and reassessing studied plant extracts for the development of ethnopharmacology-based innovative treatments for chronic pain. This review suggests that monoterpene solutions, based on composition from traditional healing herbs, offer an interesting avenue for the development of new phytotherapeutic treatments to alleviate chronic inflammatory pain conditions. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9373873/ /pubmed/35966017 http://dx.doi.org/10.3389/fnmol.2022.945450 Text en Copyright © 2022 Petitjean, Héberlé, Hilfiger, Łapieś, Rodrigue and Charlet. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Petitjean, Hugues
Héberlé, Eléa
Hilfiger, Louis
Łapieś, Olga
Rodrigue, Guillaume
Charlet, Alexandre
TRP channels and monoterpenes: Past and current leads on analgesic properties
title TRP channels and monoterpenes: Past and current leads on analgesic properties
title_full TRP channels and monoterpenes: Past and current leads on analgesic properties
title_fullStr TRP channels and monoterpenes: Past and current leads on analgesic properties
title_full_unstemmed TRP channels and monoterpenes: Past and current leads on analgesic properties
title_short TRP channels and monoterpenes: Past and current leads on analgesic properties
title_sort trp channels and monoterpenes: past and current leads on analgesic properties
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373873/
https://www.ncbi.nlm.nih.gov/pubmed/35966017
http://dx.doi.org/10.3389/fnmol.2022.945450
work_keys_str_mv AT petitjeanhugues trpchannelsandmonoterpenespastandcurrentleadsonanalgesicproperties
AT heberleelea trpchannelsandmonoterpenespastandcurrentleadsonanalgesicproperties
AT hilfigerlouis trpchannelsandmonoterpenespastandcurrentleadsonanalgesicproperties
AT łapiesolga trpchannelsandmonoterpenespastandcurrentleadsonanalgesicproperties
AT rodrigueguillaume trpchannelsandmonoterpenespastandcurrentleadsonanalgesicproperties
AT charletalexandre trpchannelsandmonoterpenespastandcurrentleadsonanalgesicproperties