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TRP channels and monoterpenes: Past and current leads on analgesic properties
The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373873/ https://www.ncbi.nlm.nih.gov/pubmed/35966017 http://dx.doi.org/10.3389/fnmol.2022.945450 |
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author | Petitjean, Hugues Héberlé, Eléa Hilfiger, Louis Łapieś, Olga Rodrigue, Guillaume Charlet, Alexandre |
author_facet | Petitjean, Hugues Héberlé, Eléa Hilfiger, Louis Łapieś, Olga Rodrigue, Guillaume Charlet, Alexandre |
author_sort | Petitjean, Hugues |
collection | PubMed |
description | The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity reactions. Monoterpenes, among which pulegone and menthol, a major class of phytocompounds present in essential oils of medicinal plants, are known modulators of those TRP channels activity. In the present review, we correlate the monoterpene content of plants with their historical therapeutic properties. We then describe how monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. Finally, we discuss the importance and the potential of characterizing new plant extracts and reassessing studied plant extracts for the development of ethnopharmacology-based innovative treatments for chronic pain. This review suggests that monoterpene solutions, based on composition from traditional healing herbs, offer an interesting avenue for the development of new phytotherapeutic treatments to alleviate chronic inflammatory pain conditions. |
format | Online Article Text |
id | pubmed-9373873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93738732022-08-13 TRP channels and monoterpenes: Past and current leads on analgesic properties Petitjean, Hugues Héberlé, Eléa Hilfiger, Louis Łapieś, Olga Rodrigue, Guillaume Charlet, Alexandre Front Mol Neurosci Molecular Neuroscience The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity reactions. Monoterpenes, among which pulegone and menthol, a major class of phytocompounds present in essential oils of medicinal plants, are known modulators of those TRP channels activity. In the present review, we correlate the monoterpene content of plants with their historical therapeutic properties. We then describe how monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. Finally, we discuss the importance and the potential of characterizing new plant extracts and reassessing studied plant extracts for the development of ethnopharmacology-based innovative treatments for chronic pain. This review suggests that monoterpene solutions, based on composition from traditional healing herbs, offer an interesting avenue for the development of new phytotherapeutic treatments to alleviate chronic inflammatory pain conditions. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9373873/ /pubmed/35966017 http://dx.doi.org/10.3389/fnmol.2022.945450 Text en Copyright © 2022 Petitjean, Héberlé, Hilfiger, Łapieś, Rodrigue and Charlet. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Neuroscience Petitjean, Hugues Héberlé, Eléa Hilfiger, Louis Łapieś, Olga Rodrigue, Guillaume Charlet, Alexandre TRP channels and monoterpenes: Past and current leads on analgesic properties |
title | TRP channels and monoterpenes: Past and current leads on analgesic properties |
title_full | TRP channels and monoterpenes: Past and current leads on analgesic properties |
title_fullStr | TRP channels and monoterpenes: Past and current leads on analgesic properties |
title_full_unstemmed | TRP channels and monoterpenes: Past and current leads on analgesic properties |
title_short | TRP channels and monoterpenes: Past and current leads on analgesic properties |
title_sort | trp channels and monoterpenes: past and current leads on analgesic properties |
topic | Molecular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373873/ https://www.ncbi.nlm.nih.gov/pubmed/35966017 http://dx.doi.org/10.3389/fnmol.2022.945450 |
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