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m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma
N6-methyladenosine (m6A) methylation, one of the most crucial RNA modifications, has been proven to play a key role that affect prognosis of soft tissue sarcoma (STS). However, m6A methylation potential role in STS metabolic processes remains unknown. We comprehensively estimated the m6A metabolic m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374037/ https://www.ncbi.nlm.nih.gov/pubmed/35967408 http://dx.doi.org/10.3389/fimmu.2022.895465 |
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author | Huang, Zhen-Dong Fu, Yong-Cheng Liu, Shu-Yan Mao, Ya-Juan Zhang, Yan Hu, Chao Wei, Ren-Xiong |
author_facet | Huang, Zhen-Dong Fu, Yong-Cheng Liu, Shu-Yan Mao, Ya-Juan Zhang, Yan Hu, Chao Wei, Ren-Xiong |
author_sort | Huang, Zhen-Dong |
collection | PubMed |
description | N6-methyladenosine (m6A) methylation, one of the most crucial RNA modifications, has been proven to play a key role that affect prognosis of soft tissue sarcoma (STS). However, m6A methylation potential role in STS metabolic processes remains unknown. We comprehensively estimated the m6A metabolic molecular subtypes and corresponding survival, immunity, genomic and stemness characteristics based on 568 STS samples and m6A related metabolic pathways. Then, to quantify the m6A metabolic subtypes, machine learning algorithms were used to develop the m6A-metabolic Scores of individual patients. Finally, two distinct m6A metabolic subtypes (Cluster A and Cluster B) among the STS patients were identified. Compared to Cluster B subtype, the Cluster A subtype was mainly characterized by better survival advantages, activated anti-tumor immune microenvironment, lower gene mutation frequency and higher anti-PD-1 immunotherapy response rates. We also found that the m6A-metabolic Scores could accurately predict the molecular subtype of STS, prognosis, the abundance of immune cell infiltration, tumor metastasis status, sensitivity to chemotherapeutics and immunotherapy response. In general, this study revealed that m6A-regulated tumor metabolism processes played a key role in terms of prognosis of STS, tumor progression, and immune microenvironment. The identification of metabolic molecular subtypes and the construction of m6A-metabolic Score will help to more effectively guide immunotherapy, metabolic therapy and chemotherapy in STS. |
format | Online Article Text |
id | pubmed-9374037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93740372022-08-13 m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma Huang, Zhen-Dong Fu, Yong-Cheng Liu, Shu-Yan Mao, Ya-Juan Zhang, Yan Hu, Chao Wei, Ren-Xiong Front Immunol Immunology N6-methyladenosine (m6A) methylation, one of the most crucial RNA modifications, has been proven to play a key role that affect prognosis of soft tissue sarcoma (STS). However, m6A methylation potential role in STS metabolic processes remains unknown. We comprehensively estimated the m6A metabolic molecular subtypes and corresponding survival, immunity, genomic and stemness characteristics based on 568 STS samples and m6A related metabolic pathways. Then, to quantify the m6A metabolic subtypes, machine learning algorithms were used to develop the m6A-metabolic Scores of individual patients. Finally, two distinct m6A metabolic subtypes (Cluster A and Cluster B) among the STS patients were identified. Compared to Cluster B subtype, the Cluster A subtype was mainly characterized by better survival advantages, activated anti-tumor immune microenvironment, lower gene mutation frequency and higher anti-PD-1 immunotherapy response rates. We also found that the m6A-metabolic Scores could accurately predict the molecular subtype of STS, prognosis, the abundance of immune cell infiltration, tumor metastasis status, sensitivity to chemotherapeutics and immunotherapy response. In general, this study revealed that m6A-regulated tumor metabolism processes played a key role in terms of prognosis of STS, tumor progression, and immune microenvironment. The identification of metabolic molecular subtypes and the construction of m6A-metabolic Score will help to more effectively guide immunotherapy, metabolic therapy and chemotherapy in STS. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9374037/ /pubmed/35967408 http://dx.doi.org/10.3389/fimmu.2022.895465 Text en Copyright © 2022 Huang, Fu, Liu, Mao, Zhang, Hu and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Huang, Zhen-Dong Fu, Yong-Cheng Liu, Shu-Yan Mao, Ya-Juan Zhang, Yan Hu, Chao Wei, Ren-Xiong m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma |
title | m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma |
title_full | m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma |
title_fullStr | m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma |
title_full_unstemmed | m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma |
title_short | m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma |
title_sort | m6a-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374037/ https://www.ncbi.nlm.nih.gov/pubmed/35967408 http://dx.doi.org/10.3389/fimmu.2022.895465 |
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