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Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques

BACKGROUND: Plaque instability is a leading cause of morbidity and mortality in coronary artery disease (CAD) patients. Numerous efforts have been made to figure out and manage unstable plaques prior to major cardiovascular events incidence. The current study aims to assess the values of the atherog...

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Autores principales: Khosravi, Arezoo, Sadeghi, Masoumeh, Farsani, Ehsan Shirvani, Danesh, Manizheh, Heshmat-Ghahdarijani, Kiyan, Roohafza, Hamidreza, Safaei, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374144/
https://www.ncbi.nlm.nih.gov/pubmed/35968214
http://dx.doi.org/10.4103/jrms.jrms_590_21
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author Khosravi, Arezoo
Sadeghi, Masoumeh
Farsani, Ehsan Shirvani
Danesh, Manizheh
Heshmat-Ghahdarijani, Kiyan
Roohafza, Hamidreza
Safaei, Ali
author_facet Khosravi, Arezoo
Sadeghi, Masoumeh
Farsani, Ehsan Shirvani
Danesh, Manizheh
Heshmat-Ghahdarijani, Kiyan
Roohafza, Hamidreza
Safaei, Ali
author_sort Khosravi, Arezoo
collection PubMed
description BACKGROUND: Plaque instability is a leading cause of morbidity and mortality in coronary artery disease (CAD) patients. Numerous efforts have been made to figure out and manage unstable plaques prior to major cardiovascular events incidence. The current study aims to assess the values of the atherogenic index of plasma (AIP) to detect unstable plaques. MATERIALS AND METHODS: The current case-control study was conducted on 435 patients who underwent percutaneous coronary intervention due to chronic stable angina (stable plaques, n = 145) or acute coronary syndrome (unstable plaques, n = 290). The demographic, comorbidities, chronic medications, biochemical and hematological characteristics of the patients were entered into the study checklist. The baseline AIP was measured according to the formula of triglycerides/high-density lipoprotein logarithm. Binary logistic regression was applied to investigate the standalone association of AIP with plaque instability. Receiver operating curve (ROC) was depicted to determine a cut-off, specificity, and sensitivity of AIP in unstable plaques diagnosis. RESULTS: AIP was an independent predictor for atherogenic plaque unstability in both crude (odds ratio [OR]: 3.677, 95% confidence interval [CI]: 1.521–8.890; P = 0.004) and full-adjusted models (OR: 15, 95% CI: 2.77–81.157; P = 0.002). According to ROC curve, at cut-point level of 0.62, AIP had sensitivity and specificity of 89.70% and 34% to detect unstable plaques, respectively (area under the curve: 0.648, 95% CI: 0.601–0.692, P < 0.001). CONCLUSION: According to this study, at the threshold of 0.62, AIP as an independent biomarker associated with plaque instability can be considered a screening tool for patients at increased risk for adverse events due to unstable atherosclerotic plaques.
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spelling pubmed-93741442022-08-13 Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques Khosravi, Arezoo Sadeghi, Masoumeh Farsani, Ehsan Shirvani Danesh, Manizheh Heshmat-Ghahdarijani, Kiyan Roohafza, Hamidreza Safaei, Ali J Res Med Sci Original Article BACKGROUND: Plaque instability is a leading cause of morbidity and mortality in coronary artery disease (CAD) patients. Numerous efforts have been made to figure out and manage unstable plaques prior to major cardiovascular events incidence. The current study aims to assess the values of the atherogenic index of plasma (AIP) to detect unstable plaques. MATERIALS AND METHODS: The current case-control study was conducted on 435 patients who underwent percutaneous coronary intervention due to chronic stable angina (stable plaques, n = 145) or acute coronary syndrome (unstable plaques, n = 290). The demographic, comorbidities, chronic medications, biochemical and hematological characteristics of the patients were entered into the study checklist. The baseline AIP was measured according to the formula of triglycerides/high-density lipoprotein logarithm. Binary logistic regression was applied to investigate the standalone association of AIP with plaque instability. Receiver operating curve (ROC) was depicted to determine a cut-off, specificity, and sensitivity of AIP in unstable plaques diagnosis. RESULTS: AIP was an independent predictor for atherogenic plaque unstability in both crude (odds ratio [OR]: 3.677, 95% confidence interval [CI]: 1.521–8.890; P = 0.004) and full-adjusted models (OR: 15, 95% CI: 2.77–81.157; P = 0.002). According to ROC curve, at cut-point level of 0.62, AIP had sensitivity and specificity of 89.70% and 34% to detect unstable plaques, respectively (area under the curve: 0.648, 95% CI: 0.601–0.692, P < 0.001). CONCLUSION: According to this study, at the threshold of 0.62, AIP as an independent biomarker associated with plaque instability can be considered a screening tool for patients at increased risk for adverse events due to unstable atherosclerotic plaques. Wolters Kluwer - Medknow 2022-06-30 /pmc/articles/PMC9374144/ /pubmed/35968214 http://dx.doi.org/10.4103/jrms.jrms_590_21 Text en Copyright: © 2022 Journal of Research in Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Khosravi, Arezoo
Sadeghi, Masoumeh
Farsani, Ehsan Shirvani
Danesh, Manizheh
Heshmat-Ghahdarijani, Kiyan
Roohafza, Hamidreza
Safaei, Ali
Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques
title Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques
title_full Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques
title_fullStr Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques
title_full_unstemmed Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques
title_short Atherogenic index of plasma: A valuable novel index to distinguish patients with unstable atherogenic plaques
title_sort atherogenic index of plasma: a valuable novel index to distinguish patients with unstable atherogenic plaques
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374144/
https://www.ncbi.nlm.nih.gov/pubmed/35968214
http://dx.doi.org/10.4103/jrms.jrms_590_21
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