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The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial

BACKGROUND: This study aims to evaluate the effect of symbiotic (Pedilact) on the treatment of infantile colic. MATERIALS AND METHODS: In this randomized clinical trial in Zanjan, Iran, 76 infants with infantile colic were assigned to two groups of 38 cases using block randomization. The interventio...

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Autores principales: Khoshnevisasl, Parisa, Sadeghzadeh, Mansour, Kamali, Koorosh, Hasanlo, Masoumeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374146/
https://www.ncbi.nlm.nih.gov/pubmed/35968208
http://dx.doi.org/10.4103/jrms.jrms_128_21
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author Khoshnevisasl, Parisa
Sadeghzadeh, Mansour
Kamali, Koorosh
Hasanlo, Masoumeh
author_facet Khoshnevisasl, Parisa
Sadeghzadeh, Mansour
Kamali, Koorosh
Hasanlo, Masoumeh
author_sort Khoshnevisasl, Parisa
collection PubMed
description BACKGROUND: This study aims to evaluate the effect of symbiotic (Pedilact) on the treatment of infantile colic. MATERIALS AND METHODS: In this randomized clinical trial in Zanjan, Iran, 76 infants with infantile colic were assigned to two groups of 38 cases using block randomization. The intervention group received 5 drops of Pedilact, a symbiotic containing Lactobacillus reuteri and simethicone (20 mg twice daily), and the control group received placebo in addition to simethicone for 4 weeks. Daily crying time, number of crying attacks per day, and sleep duration were recorded on days 1, 7, 14, 21, and 28, and the results were compared. RESULTS: Thirty-three infants in the intervention group and 35 infants in the control group were enrolled. There was no significant difference between the two groups in terms of age, gender, gestational age, maternal age, type of delivery, type of feeding, and weight at the beginning and the end of the study (all P > 0.05). Daily crying time in the control and intervention groups decreased from 240 and 210 min/day, respectively, to 0 min/day in both the groups. Daily crying attacks decreased from 5 and 4/day in the control and intervention groups, respectively, to 0/day. Sleep duration in both the groups increased from 720 to 840 and 930 min/day in the control and intervention groups, respectively, but the changes were not significant (P = 0.56, P = 0.52, and P = 0.13, respectively). CONCLUSION: We did not find a significant improvement in colic symptoms in infants receiving symbiotic compared to placebo.
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spelling pubmed-93741462022-08-13 The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial Khoshnevisasl, Parisa Sadeghzadeh, Mansour Kamali, Koorosh Hasanlo, Masoumeh J Res Med Sci Original Article BACKGROUND: This study aims to evaluate the effect of symbiotic (Pedilact) on the treatment of infantile colic. MATERIALS AND METHODS: In this randomized clinical trial in Zanjan, Iran, 76 infants with infantile colic were assigned to two groups of 38 cases using block randomization. The intervention group received 5 drops of Pedilact, a symbiotic containing Lactobacillus reuteri and simethicone (20 mg twice daily), and the control group received placebo in addition to simethicone for 4 weeks. Daily crying time, number of crying attacks per day, and sleep duration were recorded on days 1, 7, 14, 21, and 28, and the results were compared. RESULTS: Thirty-three infants in the intervention group and 35 infants in the control group were enrolled. There was no significant difference between the two groups in terms of age, gender, gestational age, maternal age, type of delivery, type of feeding, and weight at the beginning and the end of the study (all P > 0.05). Daily crying time in the control and intervention groups decreased from 240 and 210 min/day, respectively, to 0 min/day in both the groups. Daily crying attacks decreased from 5 and 4/day in the control and intervention groups, respectively, to 0/day. Sleep duration in both the groups increased from 720 to 840 and 930 min/day in the control and intervention groups, respectively, but the changes were not significant (P = 0.56, P = 0.52, and P = 0.13, respectively). CONCLUSION: We did not find a significant improvement in colic symptoms in infants receiving symbiotic compared to placebo. Wolters Kluwer - Medknow 2022-05-30 /pmc/articles/PMC9374146/ /pubmed/35968208 http://dx.doi.org/10.4103/jrms.jrms_128_21 Text en Copyright: © 2022 Journal of Research in Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Khoshnevisasl, Parisa
Sadeghzadeh, Mansour
Kamali, Koorosh
Hasanlo, Masoumeh
The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial
title The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial
title_full The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial
title_fullStr The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial
title_full_unstemmed The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial
title_short The effect of symbiotic in the treatment of infantile colic: A double-blind, randomized, placebo-controlled clinical trial
title_sort effect of symbiotic in the treatment of infantile colic: a double-blind, randomized, placebo-controlled clinical trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374146/
https://www.ncbi.nlm.nih.gov/pubmed/35968208
http://dx.doi.org/10.4103/jrms.jrms_128_21
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