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Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors

BACKGROUND: Available data suggest that obesity is related to changes in the several adipocyte-derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation between obesity with metalloproteinase-9 (MMP-9), adiponectin and adiponectin a...

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Autores principales: Babaei, Zeinab, Parsian, Hadi, Korani, Bahare, Mostafazadeh, Amrollah, Moslemi, Dariush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374150/
https://www.ncbi.nlm.nih.gov/pubmed/35968203
http://dx.doi.org/10.4103/jrms.JRMS_453_20
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author Babaei, Zeinab
Parsian, Hadi
Korani, Bahare
Mostafazadeh, Amrollah
Moslemi, Dariush
author_facet Babaei, Zeinab
Parsian, Hadi
Korani, Bahare
Mostafazadeh, Amrollah
Moslemi, Dariush
author_sort Babaei, Zeinab
collection PubMed
description BACKGROUND: Available data suggest that obesity is related to changes in the several adipocyte-derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation between obesity with metalloproteinase-9 (MMP-9), adiponectin and adiponectin and AMP-activated protein kinase (AMPK) levels by comparing serum levels of MMP-9, AMPK in normal weight and obese breast cancer survivors. MATERIALS AND METHODS: In this cross-sectional study, 30 normal weight breast cancer survivors (body mass index [BMI] 18.5-25 kg/m(2)) and 30 obese breast cancer survivors (BMI ≥30 kg/m(2)) were investigated. Anthropometric parameters and serum levels of MMP-9, adiponectin, and AMPK were compared between the two groups. RESULTS: No differences were detected in the serum levels of MMP-9, adiponectin, and AMPK in obese patients and normal weight patients (P > 0.05). There were no correlations between MMP-9, adiponectin, and AMPK levels with anthropometric measurements in two groups (P > 0.05). CONCLUSION: We found that there was a lack of correlation between obesity measures and serum levels of MMP-9, adiponectin, and AMPK. In breast cancer survivors, it seems that circulating levels of adiponectin, AMPK, and MMP-9 do not change in obesity state.
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spelling pubmed-93741502022-08-13 Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors Babaei, Zeinab Parsian, Hadi Korani, Bahare Mostafazadeh, Amrollah Moslemi, Dariush J Res Med Sci Original Article BACKGROUND: Available data suggest that obesity is related to changes in the several adipocyte-derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation between obesity with metalloproteinase-9 (MMP-9), adiponectin and adiponectin and AMP-activated protein kinase (AMPK) levels by comparing serum levels of MMP-9, AMPK in normal weight and obese breast cancer survivors. MATERIALS AND METHODS: In this cross-sectional study, 30 normal weight breast cancer survivors (body mass index [BMI] 18.5-25 kg/m(2)) and 30 obese breast cancer survivors (BMI ≥30 kg/m(2)) were investigated. Anthropometric parameters and serum levels of MMP-9, adiponectin, and AMPK were compared between the two groups. RESULTS: No differences were detected in the serum levels of MMP-9, adiponectin, and AMPK in obese patients and normal weight patients (P > 0.05). There were no correlations between MMP-9, adiponectin, and AMPK levels with anthropometric measurements in two groups (P > 0.05). CONCLUSION: We found that there was a lack of correlation between obesity measures and serum levels of MMP-9, adiponectin, and AMPK. In breast cancer survivors, it seems that circulating levels of adiponectin, AMPK, and MMP-9 do not change in obesity state. Wolters Kluwer - Medknow 2022-06-30 /pmc/articles/PMC9374150/ /pubmed/35968203 http://dx.doi.org/10.4103/jrms.JRMS_453_20 Text en Copyright: © 2022 Journal of Research in Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Babaei, Zeinab
Parsian, Hadi
Korani, Bahare
Mostafazadeh, Amrollah
Moslemi, Dariush
Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors
title Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors
title_full Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors
title_fullStr Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors
title_full_unstemmed Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors
title_short Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors
title_sort body composition and serum levels of matrix metalloproteinase-9, adiponectin and amp-activated protein kinase in breast cancer survivors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374150/
https://www.ncbi.nlm.nih.gov/pubmed/35968203
http://dx.doi.org/10.4103/jrms.JRMS_453_20
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