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Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity and mortality. Short-term exposure to fine particulate matter (PM(2.5)) has been causally linked to higher risk of cardiovascular disease, but the association with atrial fibrillation (AF) is...

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Autores principales: Dahlquist, Marcus, Frykman, Viveka, Stafoggia, Massimo, Qvarnström, Eva, Wellenius, Gregory A., Ljungman, Petter L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374182/
https://www.ncbi.nlm.nih.gov/pubmed/35975167
http://dx.doi.org/10.1097/EE9.0000000000000215
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author Dahlquist, Marcus
Frykman, Viveka
Stafoggia, Massimo
Qvarnström, Eva
Wellenius, Gregory A.
Ljungman, Petter L. S.
author_facet Dahlquist, Marcus
Frykman, Viveka
Stafoggia, Massimo
Qvarnström, Eva
Wellenius, Gregory A.
Ljungman, Petter L. S.
author_sort Dahlquist, Marcus
collection PubMed
description Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity and mortality. Short-term exposure to fine particulate matter (PM(2.5)) has been causally linked to higher risk of cardiovascular disease, but the association with atrial fibrillation (AF) is less clear. METHODS: We conducted a time-stratified case-crossover study to estimate the association between short-term air pollution levels and risk of AF episodes. The episodes were identified among patients with paroxysmal AF and an intracardiac devices able to register and store AF episodes. We obtained air pollution and temperature data from fixed monitoring stations and used conditional logistic regression to quantify the association of PM(2.5), particulate matter (PM(10)), nitrogen dioxide (NO(2)) and ozone (O(3)) with onset of AF episodes, adjusting for temperature and public holidays.”. RESULTS: We analyzed 584 episodes of AF from 91 participants and observed increased risk of AF episodes with PM(2.5) levels for the 48–72 hours lag (OR 1.05; CI [1.01,1.09] per IQR)] and 72–96 hours (OR 1.05 CI [1.00,1.10] per IQR). Our results were suggestive of an association between O(3) levels and AF episodes during the warm season. We did not observe any statistically significant associations for PM(10) nor NO(2). CONCLUSION: Short-term increases in PM(2.5) in a low-pollution level environment were associated with increased risk of AF episodes in a population with intracardiac devices. Our findings add to the evidence of a potential triggering of AF by short-term increases in air pollution levels, well below the new WHO air quality guidelines.
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spelling pubmed-93741822022-08-15 Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices Dahlquist, Marcus Frykman, Viveka Stafoggia, Massimo Qvarnström, Eva Wellenius, Gregory A. Ljungman, Petter L. S. Environ Epidemiol Original Research Article Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity and mortality. Short-term exposure to fine particulate matter (PM(2.5)) has been causally linked to higher risk of cardiovascular disease, but the association with atrial fibrillation (AF) is less clear. METHODS: We conducted a time-stratified case-crossover study to estimate the association between short-term air pollution levels and risk of AF episodes. The episodes were identified among patients with paroxysmal AF and an intracardiac devices able to register and store AF episodes. We obtained air pollution and temperature data from fixed monitoring stations and used conditional logistic regression to quantify the association of PM(2.5), particulate matter (PM(10)), nitrogen dioxide (NO(2)) and ozone (O(3)) with onset of AF episodes, adjusting for temperature and public holidays.”. RESULTS: We analyzed 584 episodes of AF from 91 participants and observed increased risk of AF episodes with PM(2.5) levels for the 48–72 hours lag (OR 1.05; CI [1.01,1.09] per IQR)] and 72–96 hours (OR 1.05 CI [1.00,1.10] per IQR). Our results were suggestive of an association between O(3) levels and AF episodes during the warm season. We did not observe any statistically significant associations for PM(10) nor NO(2). CONCLUSION: Short-term increases in PM(2.5) in a low-pollution level environment were associated with increased risk of AF episodes in a population with intracardiac devices. Our findings add to the evidence of a potential triggering of AF by short-term increases in air pollution levels, well below the new WHO air quality guidelines. Lippincott Williams & Wilkins 2022-07-22 /pmc/articles/PMC9374182/ /pubmed/35975167 http://dx.doi.org/10.1097/EE9.0000000000000215 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Article
Dahlquist, Marcus
Frykman, Viveka
Stafoggia, Massimo
Qvarnström, Eva
Wellenius, Gregory A.
Ljungman, Petter L. S.
Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices
title Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices
title_full Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices
title_fullStr Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices
title_full_unstemmed Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices
title_short Short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices
title_sort short-term ambient air pollution exposure and risk of atrial fibrillation in patients with intracardiac devices
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374182/
https://www.ncbi.nlm.nih.gov/pubmed/35975167
http://dx.doi.org/10.1097/EE9.0000000000000215
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