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Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort

Inverse associations between natural vegetation exposure (i.e., greenness) and breast cancer risk have been reported; however, it remains unknown whether greenness affects breast tissue development or operates through other mechanisms (e.g., body mass index [BMI] or physical activity). We examined t...

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Autores principales: Blair, Lyndsey K., Warner, Erica T., James, Peter, Hart, Jaime E., VoPham, Trang, Barnard, Mollie E., Newton, Johnnie D., Murthy, Divya J., Laden, Francine, Tamimi, Rulla M., DuPre, Natalie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374192/
https://www.ncbi.nlm.nih.gov/pubmed/35975164
http://dx.doi.org/10.1097/EE9.0000000000000216
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author Blair, Lyndsey K.
Warner, Erica T.
James, Peter
Hart, Jaime E.
VoPham, Trang
Barnard, Mollie E.
Newton, Johnnie D.
Murthy, Divya J.
Laden, Francine
Tamimi, Rulla M.
DuPre, Natalie C.
author_facet Blair, Lyndsey K.
Warner, Erica T.
James, Peter
Hart, Jaime E.
VoPham, Trang
Barnard, Mollie E.
Newton, Johnnie D.
Murthy, Divya J.
Laden, Francine
Tamimi, Rulla M.
DuPre, Natalie C.
author_sort Blair, Lyndsey K.
collection PubMed
description Inverse associations between natural vegetation exposure (i.e., greenness) and breast cancer risk have been reported; however, it remains unknown whether greenness affects breast tissue development or operates through other mechanisms (e.g., body mass index [BMI] or physical activity). We examined the association between greenness and mammographic density—a strong breast cancer risk factor—to determine whether greenness influences breast tissue composition independent of lifestyle factors. METHODS: Women (n = 2,318) without a history of breast cancer underwent mammographic screening at Brigham and Women’s Hospital in Boston, Massachusetts, from 2006 to 2014. Normalized Difference Vegetation Index (NDVI) satellite data at 1-km(2) resolution were used to estimate greenness at participants’ residential address 1, 3, and 5 years before mammogram. We used multivariable linear regression to estimate differences in log-transformed volumetric mammographic density measures and 95% confidence intervals (CIs) for each 0.1 unit increase in NDVI. RESULTS: Five-year annual average NDVI was not associated with percent mammographic density in premenopausal (β = –0.01; 95% CI = –0.03, 0.02; P = 0.58) and postmenopausal women (β = –0.02; 95% CI = –0.04, 0.01; P = 0.18). Results were similar for 1-year and 3-year NDVI measures and in models including potential mediators of BMI and physical activity. There were also no associations between greenness and dense volume and nondense volume. CONCLUSIONS: Greenness exposures were not associated with mammographic density. IMPACT: Prior observations of a protective association between greenness and breast cancer may not be driven by differences in breast tissue composition, as measured by mammographic density, but rather other mechanisms.
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spelling pubmed-93741922022-08-15 Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort Blair, Lyndsey K. Warner, Erica T. James, Peter Hart, Jaime E. VoPham, Trang Barnard, Mollie E. Newton, Johnnie D. Murthy, Divya J. Laden, Francine Tamimi, Rulla M. DuPre, Natalie C. Environ Epidemiol Original Research Article Inverse associations between natural vegetation exposure (i.e., greenness) and breast cancer risk have been reported; however, it remains unknown whether greenness affects breast tissue development or operates through other mechanisms (e.g., body mass index [BMI] or physical activity). We examined the association between greenness and mammographic density—a strong breast cancer risk factor—to determine whether greenness influences breast tissue composition independent of lifestyle factors. METHODS: Women (n = 2,318) without a history of breast cancer underwent mammographic screening at Brigham and Women’s Hospital in Boston, Massachusetts, from 2006 to 2014. Normalized Difference Vegetation Index (NDVI) satellite data at 1-km(2) resolution were used to estimate greenness at participants’ residential address 1, 3, and 5 years before mammogram. We used multivariable linear regression to estimate differences in log-transformed volumetric mammographic density measures and 95% confidence intervals (CIs) for each 0.1 unit increase in NDVI. RESULTS: Five-year annual average NDVI was not associated with percent mammographic density in premenopausal (β = –0.01; 95% CI = –0.03, 0.02; P = 0.58) and postmenopausal women (β = –0.02; 95% CI = –0.04, 0.01; P = 0.18). Results were similar for 1-year and 3-year NDVI measures and in models including potential mediators of BMI and physical activity. There were also no associations between greenness and dense volume and nondense volume. CONCLUSIONS: Greenness exposures were not associated with mammographic density. IMPACT: Prior observations of a protective association between greenness and breast cancer may not be driven by differences in breast tissue composition, as measured by mammographic density, but rather other mechanisms. Lippincott Williams & Wilkins 2022-07-19 /pmc/articles/PMC9374192/ /pubmed/35975164 http://dx.doi.org/10.1097/EE9.0000000000000216 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Article
Blair, Lyndsey K.
Warner, Erica T.
James, Peter
Hart, Jaime E.
VoPham, Trang
Barnard, Mollie E.
Newton, Johnnie D.
Murthy, Divya J.
Laden, Francine
Tamimi, Rulla M.
DuPre, Natalie C.
Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort
title Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort
title_full Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort
title_fullStr Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort
title_full_unstemmed Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort
title_short Exposure to natural vegetation in relation to mammographic density in a Massachusetts-based clinical cohort
title_sort exposure to natural vegetation in relation to mammographic density in a massachusetts-based clinical cohort
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374192/
https://www.ncbi.nlm.nih.gov/pubmed/35975164
http://dx.doi.org/10.1097/EE9.0000000000000216
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