Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation

As a critical immune checkpoint molecule, PD-L1 is expressed at significantly higher levels in multiple neoplastic tissues compared to normal ones. PD-L1/PD-1 axis is a critical target for tumor immunotherapy, blocking the PD-L1/PD-1 axis is recognized and has achieved unprecedented success in clini...

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Detalles Bibliográficos
Autores principales: Wei, Meng, Mo, Yunhai, Liu, Jialong, Zhai, Jingtong, Li, Huilong, Xu, Yixin, Peng, Yumeng, Tang, Zhihong, Wei, Tao, Yang, Xiaopan, Huang, Linfei, Shao, Xiao, Li, Jingfei, Zhou, Li, Zhong, Hui, Wei, Congwen, Xie, Qiaosheng, Min, Min, Wu, Feixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374197/
https://www.ncbi.nlm.nih.gov/pubmed/35965501
http://dx.doi.org/10.3389/fonc.2022.835603

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