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Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape

The Delta variant is one of the alarming variants of the SARS-CoV-2 virus that have been immensely detrimental and a significant cause of the prolonged pandemic (B.1.617.2). During the SARS-CoV-2 pandemic from December 2020 to October 2021, the Delta variant showed global dominance, and afterwards,...

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Autores principales: Bhattacharya, Manojit, Chatterjee, Srijan, Sharma, Ashish Ranjan, Lee, Sang-Soo, Chakraborty, Chiranjib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374302/
https://www.ncbi.nlm.nih.gov/pubmed/35962276
http://dx.doi.org/10.1007/s12223-022-01001-3
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author Bhattacharya, Manojit
Chatterjee, Srijan
Sharma, Ashish Ranjan
Lee, Sang-Soo
Chakraborty, Chiranjib
author_facet Bhattacharya, Manojit
Chatterjee, Srijan
Sharma, Ashish Ranjan
Lee, Sang-Soo
Chakraborty, Chiranjib
author_sort Bhattacharya, Manojit
collection PubMed
description The Delta variant is one of the alarming variants of the SARS-CoV-2 virus that have been immensely detrimental and a significant cause of the prolonged pandemic (B.1.617.2). During the SARS-CoV-2 pandemic from December 2020 to October 2021, the Delta variant showed global dominance, and afterwards, the Omicron variant showed global dominance. Delta shows high infectivity rate which accounted for nearly 70% of the cases after December 2020. This review discusses the additional attributes that make the Delta variant so infectious and transmissible. The study also focuses on the significant mutations, namely the L452R and T478K present on the receptor-binding domain of spike (S)-glycoprotein, which confers specific alterations to the Delta variant. Considerably, we have also highlighted other notable factors such as the immune escape, infectivity and re-infectivity, vaccine escape, Ro number, S-glycoprotein stability, cleavage pattern, and its binding affinity with the host cell receptor protein. We have also emphasized clinical manifestations, symptomatology, morbidity, and mortality for the Delta variant compared with other significant SARS-CoV-2 variants. This review will help the researchers to get an elucidative view of the Delta variant to adopt some practical strategies to minimize the escalating spread of the SARS-CoV-2 Delta variant.
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spelling pubmed-93743022022-08-12 Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape Bhattacharya, Manojit Chatterjee, Srijan Sharma, Ashish Ranjan Lee, Sang-Soo Chakraborty, Chiranjib Folia Microbiol (Praha) Review The Delta variant is one of the alarming variants of the SARS-CoV-2 virus that have been immensely detrimental and a significant cause of the prolonged pandemic (B.1.617.2). During the SARS-CoV-2 pandemic from December 2020 to October 2021, the Delta variant showed global dominance, and afterwards, the Omicron variant showed global dominance. Delta shows high infectivity rate which accounted for nearly 70% of the cases after December 2020. This review discusses the additional attributes that make the Delta variant so infectious and transmissible. The study also focuses on the significant mutations, namely the L452R and T478K present on the receptor-binding domain of spike (S)-glycoprotein, which confers specific alterations to the Delta variant. Considerably, we have also highlighted other notable factors such as the immune escape, infectivity and re-infectivity, vaccine escape, Ro number, S-glycoprotein stability, cleavage pattern, and its binding affinity with the host cell receptor protein. We have also emphasized clinical manifestations, symptomatology, morbidity, and mortality for the Delta variant compared with other significant SARS-CoV-2 variants. This review will help the researchers to get an elucidative view of the Delta variant to adopt some practical strategies to minimize the escalating spread of the SARS-CoV-2 Delta variant. Springer Netherlands 2022-08-12 2023 /pmc/articles/PMC9374302/ /pubmed/35962276 http://dx.doi.org/10.1007/s12223-022-01001-3 Text en © Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i. 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Bhattacharya, Manojit
Chatterjee, Srijan
Sharma, Ashish Ranjan
Lee, Sang-Soo
Chakraborty, Chiranjib
Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape
title Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape
title_full Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape
title_fullStr Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape
title_full_unstemmed Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape
title_short Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape
title_sort delta variant (b.1.617.2) of sars-cov-2: current understanding of infection, transmission, immune escape, and mutational landscape
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374302/
https://www.ncbi.nlm.nih.gov/pubmed/35962276
http://dx.doi.org/10.1007/s12223-022-01001-3
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