A naturally arising broad and potent CD4-binding site antibody with low somatic mutation

The induction of broadly neutralizing antibodies (bNAbs) is a potential strategy for a vaccine against HIV-1. However, most bNAbs exhibit features such as unusually high somatic hypermutation, including insertions and deletions, which make their induction challenging. VRC01-class bNAbs not only exhi...

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Detalles Bibliográficos
Autores principales: Barnes, Christopher O., Schoofs, Till, Gnanapragasam, Priyanthi N.P., Golijanin, Jovana, Huey-Tubman, Kathryn E., Gruell, Henning, Schommers, Philipp, Suh-Toma, Nina, Lee, Yu Erica, Cetrulo Lorenzi, Julio C., Piechocka-Trocha, Alicja, Scheid, Johannes F., West, Anthony P., Walker, Bruce D., Seaman, Michael S., Klein, Florian, Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374330/
https://www.ncbi.nlm.nih.gov/pubmed/35960796
http://dx.doi.org/10.1126/sciadv.abp8155

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