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Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity

Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is incompletely understood. Here, we identify two immune...

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Detalles Bibliográficos
Autores principales:	Abt, Evan R., Rashid, Khalid, Le, Thuc M., Li, Suwen, Lee, Hailey R., Lok, Vincent, Li, Luyi, Creech, Amanda L., Labora, Amanda N., Mandl, Hanna K., Lam, Alex K., Cho, Arthur, Rezek, Valerie, Wu, Nanping, Abril-Rodriguez, Gabriel, Rosser, Ethan W., Mittelman, Steven D., Hugo, Willy, Mehrling, Thomas, Bantia, Shanta, Ribas, Antoni, Donahue, Timothy R., Crooks, Gay M., Wu, Ting-Ting, Radu, Caius G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374381/ https://www.ncbi.nlm.nih.gov/pubmed/35653193 http://dx.doi.org/10.1172/JCI160852

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