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Methotrexate Inhibits T Cell Proliferation but Not Inflammatory Cytokine Expression to Modulate Immunity in People Living With HIV

Inflammation associated with increased risk of comorbidities persists in people living with HIV (PWH) on combination antiretroviral therapy (ART). A recent placebo-controlled trial of low-dose methotrexate (MTX) in PWH found that numbers of total CD4 and CD8 T cells decreased in the low-dose MTX arm...

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Detalles Bibliográficos
Autores principales:	Freeman, Michael L., Clagett, Brian M., Moisi, Daniela, Yeh, Eunice, Morris, Charles D., Ryu, Angela, Rodriguez, Benigno, Stein, James H., Deeks, Steven G., Currier, Judith S., Hsue, Priscilla Y., Anthony, Donald D., Calabrese, Leonard H., Ribaudo, Heather J., Lederman, Michael M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374564/ https://www.ncbi.nlm.nih.gov/pubmed/35967371 http://dx.doi.org/10.3389/fimmu.2022.924718

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