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Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms

The human pathogen Mycobacterium tuberculosis requires a P(1B)-ATPase metal exporter, CtpC (Rv3270), for resistance to zinc poisoning. Here, we show that zinc resistance also depends on a chaperone-like protein, PacL1 (Rv3269). PacL1 contains a transmembrane domain, a cytoplasmic region with glutami...

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Detalles Bibliográficos
Autores principales:	Boudehen, Yves-Marie, Faucher, Marion, Maréchal, Xavier, Miras, Roger, Rech, Jérôme, Rombouts, Yoann, Sénèque, Olivier, Wallat, Maximilian, Demange, Pascal, Bouet, Jean-Yves, Saurel, Olivier, Catty, Patrice, Gutierrez, Claude, Neyrolles, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374683/ https://www.ncbi.nlm.nih.gov/pubmed/35961955 http://dx.doi.org/10.1038/s41467-022-32085-7

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