Structural basis for receptor selectivity and inverse agonism in S1P(5) receptors

The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) - S1P(1-5). S1P(5) is predominantly expressed in nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role in immune and neurodeg...

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Detalles Bibliográficos
Autores principales: Lyapina, Elizaveta, Marin, Egor, Gusach, Anastasiia, Orekhov, Philipp, Gerasimov, Andrey, Luginina, Aleksandra, Vakhrameev, Daniil, Ergasheva, Margarita, Kovaleva, Margarita, Khusainov, Georgii, Khorn, Polina, Shevtsov, Mikhail, Kovalev, Kirill, Bukhdruker, Sergey, Okhrimenko, Ivan, Popov, Petr, Hu, Hao, Weierstall, Uwe, Liu, Wei, Cho, Yunje, Gushchin, Ivan, Rogachev, Andrey, Bourenkov, Gleb, Park, Sehan, Park, Gisu, Hyun, Hyo Jung, Park, Jaehyun, Gordeliy, Valentin, Borshchevskiy, Valentin, Mishin, Alexey, Cherezov, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374744/
https://www.ncbi.nlm.nih.gov/pubmed/35961984
http://dx.doi.org/10.1038/s41467-022-32447-1

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