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Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN(4), VN(4), and Fe-Cu-N(6) with catalytic activiti...

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Detalles Bibliográficos
Autores principales: Zhang, Shaofang, Li, Yonghui, Sun, Si, Liu, Ling, Mu, Xiaoyu, Liu, Shuhu, Jiao, Menglu, Chen, Xinzhu, Chen, Ke, Ma, Huizhen, Li, Tuo, Liu, Xiaoyu, Wang, Hao, Zhang, Jianning, Yang, Jiang, Zhang, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374753/
https://www.ncbi.nlm.nih.gov/pubmed/35961961
http://dx.doi.org/10.1038/s41467-022-32411-z
Descripción
Sumario:Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN(4), VN(4), and Fe-Cu-N(6) with catalytic activities surpassing natural enzymes. Notably, Rh/VN(4) preferably forms an Rh/V-O-N(4) active center to decrease reaction energy barriers and mediates a “two-sided oxygen-linked” reaction path, showing 4 and 5-fold higher affinities in peroxidase-like activity than the FeN(4) and natural horseradish peroxidase. Furthermore, RhN(4) presents a 20-fold improved affinity in the catalase-like activity compared to the natural catalase; Fe-Cu-N(6) displays selectivity towards the superoxide dismutase-like activity; VN(4) favors a 7-fold higher glutathione peroxidase-like activity than the natural glutathione peroxidase. Bioactive sutures with Rh/VN(4) show recyclable catalytic features without apparent decay in 1 month and accelerate the scalp healing from brain trauma by promoting the vascular endothelial growth factor, regulating the immune cells like macrophages, and diminishing inflammation.