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Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma
Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN(4), VN(4), and Fe-Cu-N(6) with catalytic activiti...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374753/ https://www.ncbi.nlm.nih.gov/pubmed/35961961 http://dx.doi.org/10.1038/s41467-022-32411-z |
Sumario: | Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN(4), VN(4), and Fe-Cu-N(6) with catalytic activities surpassing natural enzymes. Notably, Rh/VN(4) preferably forms an Rh/V-O-N(4) active center to decrease reaction energy barriers and mediates a “two-sided oxygen-linked” reaction path, showing 4 and 5-fold higher affinities in peroxidase-like activity than the FeN(4) and natural horseradish peroxidase. Furthermore, RhN(4) presents a 20-fold improved affinity in the catalase-like activity compared to the natural catalase; Fe-Cu-N(6) displays selectivity towards the superoxide dismutase-like activity; VN(4) favors a 7-fold higher glutathione peroxidase-like activity than the natural glutathione peroxidase. Bioactive sutures with Rh/VN(4) show recyclable catalytic features without apparent decay in 1 month and accelerate the scalp healing from brain trauma by promoting the vascular endothelial growth factor, regulating the immune cells like macrophages, and diminishing inflammation. |
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