Cargando…

Dynamic mechanism of GPCR-mediated β-arrestin: a potential therapeutic agent discovery of biased drug

Detalles Bibliográficos
Autores principales:	Xu, Zheng, Shao, Zhenhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Research Highlight
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374773/ https://www.ncbi.nlm.nih.gov/pubmed/35961979 http://dx.doi.org/10.1038/s41392-022-01140-6

Ejemplares similares

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
por: Janetzko, John, et al.
Publicado: (2022)

Receptor-Arrestin Interactions: The GPCR Perspective
por: Seyedabadi, Mohammad, et al.
Publicado: (2021)

Molecular mechanisms of fentanyl mediated β-arrestin biased signaling
por: de Waal, Parker W., et al.
Publicado: (2020)

Location Bias as Emerging Paradigm in GPCR Biology and Drug Discovery
por: Mohammad Nezhady, Mohammad Ali, et al.
Publicado: (2020)

Functional competence of a partially engaged GPCR–β-arrestin complex
por: Kumari, Punita, et al.
Publicado: (2016)

Unique Roles of β-Arrestin in GPCR Trafficking Revealed by Photoinducible Dimerizers
por: Takenouchi, Osamu, et al.
Publicado: (2018)

Structure, function and drug discovery of GPCR signaling
por: Cheng, Lin, et al.
Publicado: (2023)

GPCR Signaling Regulation: The Role of GRKs and Arrestins
por: Gurevich, Vsevolod V., et al.
Publicado: (2019)

G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias
por: Chen, Qiuyan, et al.
Publicado: (2022)

New Routes in GPCR/β-Arrestin-Driven Signaling in Cancer Progression and Metastasis
por: Bagnato, Anna, et al.
Publicado: (2019)

Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex
por: Nguyen, Anthony H., et al.
Publicado: (2019)

Intercellular Lipid Mediators and GPCR Drug Discovery
por: Im, Dong-Soon
Publicado: (2013)

Exploring GPCR‐arrestin interfaces with genetically encoded crosslinkers
por: Böttke, Thore, et al.
Publicado: (2020)

β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
por: Woo, Jung-AA, et al.
Publicado: (2021)

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
por: Baidya, Mithu, et al.
Publicado: (2022)

GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin
por: Yun, Yaejin, et al.
Publicado: (2023)

GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
por: Drube, J., et al.
Publicado: (2022)

Tools for GPCR drug discovery
por: Zhang, Ru, et al.
Publicado: (2012)

Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants
por: Wu, Yuxin, et al.
Publicado: (2022)

The orientation and stability of the GPCR-Arrestin complex in a lipid bilayer
por: Wang, Dali, et al.
Publicado: (2017)

Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation
por: Clark, Lisa J., et al.
Publicado: (2020)

The Predominant Role of Arrestin3 in General GPCR Desensitization in Platelets
por: Chaudhary, Preeti Kumari, et al.
Publicado: (2021)

Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor
por: Delgado-Peraza, Francheska, et al.
Publicado: (2016)

Structural Insights into the Intrinsically Disordered GPCR C-Terminal Region, Major Actor in Arrestin-GPCR Interaction
por: Guillien, Myriam, et al.
Publicado: (2022)

The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus
por: Zang, Yunxiang, et al.
Publicado: (2021)

Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling
por: Barsi-Rhyne, Benjamin, et al.
Publicado: (2022)

New discoveries on how DICER efficiently processes pre‐miRNA
por: Weng, Qi, et al.
Publicado: (2023)

β-arrestin drives MAP kinase signaling from clathrin-coated structures after GPCR dissociation
por: Eichel, K., et al.
Publicado: (2016)

Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling
por: Dwivedi-Agnihotri, Hemlata, et al.
Publicado: (2020)

Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
por: Shiraishi, Yutaro, et al.
Publicado: (2021)

Essential Dynamics Ensemble Docking for Structure-Based GPCR Drug Discovery
por: McKay, Kyle, et al.
Publicado: (2022)

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
por: Erickson, Catherine E., et al.
Publicado: (2013)

GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements
por: Zheng, Chen, et al.
Publicado: (2023)

GPCR binding and JNK3 activation by arrestin-3 have different structural requirements
por: Zheng, Chen, et al.
Publicado: (2023)

Discovery of β-lactam-resistant variants in diverse pneumococcal populations
por: Hakenbeck, Regine
Publicado: (2014)

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT(2A) Receptor Agonists
por: Poulie, Christian B. M., et al.
Publicado: (2022)

Correction for Liu et al., β-Arrestin2 is a critical component of the GPCR–eNOS signalosome
Publicado: (2022)

Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin
por: Sommer, Martha E., et al.
Publicado: (2012)

Crystal structure of a common GPCR-binding interface for G protein and arrestin
por: Szczepek, Michal, et al.
Publicado: (2014)

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes
por: Pakharukova, Natalia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dkoo82j62o3o48balm8lkv1ohp