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Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report

Hyperphagia leading to obesity is the most common cause of mortality and morbidity in Prader-Willi syndrome (PWS). It has been classified as the most common genetic cause of the development of life-threatening obesity resulting from a defect in satiety, with an onset during early childhood. Abnormal...

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Autores principales: Soomro, Faiza H, Razzaq, Aneela, Siddiq, Ghulam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375055/
https://www.ncbi.nlm.nih.gov/pubmed/35975092
http://dx.doi.org/10.7759/cureus.27955
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author Soomro, Faiza H
Razzaq, Aneela
Siddiq, Ghulam
author_facet Soomro, Faiza H
Razzaq, Aneela
Siddiq, Ghulam
author_sort Soomro, Faiza H
collection PubMed
description Hyperphagia leading to obesity is the most common cause of mortality and morbidity in Prader-Willi syndrome (PWS). It has been classified as the most common genetic cause of the development of life-threatening obesity resulting from a defect in satiety, with an onset during early childhood. Abnormalities in the feedback from gut peptides, including ghrelin, may contribute to the satiety defect; autonomic dysfunction may also play a role in impaired satiety. Usually, pharmacological treatment is ineffective in managing obesity in these patients. A 19-year-old male child with Prader-Willi syndrome presented with morbid obesity, obstructive sleep apnea, and impaired glycemic control. The patient had complained of hyperphagia since early childhood, but food intake increased aggressively in the last few years, which resulted in morbid obesity. The patient was treated with laparoscopic sleeve gastrectomy, and the residual stomach volume was 100 ml. The intervention resulted in a 37.1% weight reduction after one year of surgery with well-controlled blood sugar levels. The patient also reported improved overall quality of life, mood, and functionality. Laparoscopic sleeve gastrectomy can be offered to obese Prader-Willi syndrome patients with heightened mortality, particularly because no other effective alternative therapy is available.
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spelling pubmed-93750552022-08-15 Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report Soomro, Faiza H Razzaq, Aneela Siddiq, Ghulam Cureus Endocrinology/Diabetes/Metabolism Hyperphagia leading to obesity is the most common cause of mortality and morbidity in Prader-Willi syndrome (PWS). It has been classified as the most common genetic cause of the development of life-threatening obesity resulting from a defect in satiety, with an onset during early childhood. Abnormalities in the feedback from gut peptides, including ghrelin, may contribute to the satiety defect; autonomic dysfunction may also play a role in impaired satiety. Usually, pharmacological treatment is ineffective in managing obesity in these patients. A 19-year-old male child with Prader-Willi syndrome presented with morbid obesity, obstructive sleep apnea, and impaired glycemic control. The patient had complained of hyperphagia since early childhood, but food intake increased aggressively in the last few years, which resulted in morbid obesity. The patient was treated with laparoscopic sleeve gastrectomy, and the residual stomach volume was 100 ml. The intervention resulted in a 37.1% weight reduction after one year of surgery with well-controlled blood sugar levels. The patient also reported improved overall quality of life, mood, and functionality. Laparoscopic sleeve gastrectomy can be offered to obese Prader-Willi syndrome patients with heightened mortality, particularly because no other effective alternative therapy is available. Cureus 2022-08-12 /pmc/articles/PMC9375055/ /pubmed/35975092 http://dx.doi.org/10.7759/cureus.27955 Text en Copyright © 2022, Soomro et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Soomro, Faiza H
Razzaq, Aneela
Siddiq, Ghulam
Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report
title Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report
title_full Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report
title_fullStr Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report
title_full_unstemmed Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report
title_short Effects of Restrictive Bariatric Surgery on Congenital Prader-Willi Syndrome: A Case Report
title_sort effects of restrictive bariatric surgery on congenital prader-willi syndrome: a case report
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375055/
https://www.ncbi.nlm.nih.gov/pubmed/35975092
http://dx.doi.org/10.7759/cureus.27955
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