Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse

Actin remodeling promotes B cell activation by enabling B cell antigen receptor clustering in the immune synapse. In the current issue of JCB, Droubi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112018) find that this process is initiated by the lipid phosphatase INPP5B, which shapes s...

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Detalles Bibliográficos
Autores principales: Wang, Mitchell S., Huse, Morgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375141/
https://www.ncbi.nlm.nih.gov/pubmed/35969858
http://dx.doi.org/10.1083/jcb.202208015
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author Wang, Mitchell S.
Huse, Morgan
author_facet Wang, Mitchell S.
Huse, Morgan
author_sort Wang, Mitchell S.
collection PubMed
description Actin remodeling promotes B cell activation by enabling B cell antigen receptor clustering in the immune synapse. In the current issue of JCB, Droubi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112018) find that this process is initiated by the lipid phosphatase INPP5B, which shapes synaptic actin architecture by locally depleting phosphatidylinositol 4,5 bisphosphate.
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spelling pubmed-93751412023-02-16 Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse Wang, Mitchell S. Huse, Morgan J Cell Biol Spotlight Actin remodeling promotes B cell activation by enabling B cell antigen receptor clustering in the immune synapse. In the current issue of JCB, Droubi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112018) find that this process is initiated by the lipid phosphatase INPP5B, which shapes synaptic actin architecture by locally depleting phosphatidylinositol 4,5 bisphosphate. Rockefeller University Press 2022-08-16 /pmc/articles/PMC9375141/ /pubmed/35969858 http://dx.doi.org/10.1083/jcb.202208015 Text en © 2022 Wang and Huse https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Wang, Mitchell S.
Huse, Morgan
Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse
title Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse
title_full Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse
title_fullStr Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse
title_full_unstemmed Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse
title_short Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse
title_sort phollow the phosphoinositol: actin dynamics at the b cell immune synapse
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375141/
https://www.ncbi.nlm.nih.gov/pubmed/35969858
http://dx.doi.org/10.1083/jcb.202208015
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