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Helminths revive to survive

Helminth parasites are well known to have co-evolved a diverse arsenal of immunomodulatory factors to aid their persistence following infection. In this issue, Karo-Atar et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212311) demonstrate that products released by the gut-dwelling helminth H...

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Detalles Bibliográficos
Autores principales: Grainger, John R., Daw, Rufus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375159/
https://www.ncbi.nlm.nih.gov/pubmed/37559179
http://dx.doi.org/10.1084/jem.20221183
Descripción
Sumario:Helminth parasites are well known to have co-evolved a diverse arsenal of immunomodulatory factors to aid their persistence following infection. In this issue, Karo-Atar et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212311) demonstrate that products released by the gut-dwelling helminth Heligmosomoides polygyrus barkeri modify intestinal stem cells into a “revival” state, which is associated with a loss of helminth-expelling secretory cell types from the epithelium.