Fabrication of multifunctional metal–organic frameworks nanoparticles via layer-by-layer self-assembly to efficiently discover PSD95-nNOS uncouplers for stroke treatment

BACKGROUND: Disruption of the postsynaptic density protein-95 (PSD95)—neuronal nitric oxide synthase (nNOS) coupling is an effective way to treat ischemic stroke, however, it still faces some challenges, especially lack of satisfactory PSD95-nNOS uncouplers and the efficient high throughput screenin...

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Detalles Bibliográficos
Autores principales: Ding, Yingying, Jin, Yang, Peng, Tao, Gao, Yankun, Zang, Yang, He, Hongliang, Li, Fei, Zhang, Yu, Zhang, Hongjuan, Chen, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375364/
https://www.ncbi.nlm.nih.gov/pubmed/35964123
http://dx.doi.org/10.1186/s12951-022-01583-7

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