Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient

Pyoderma gangrenosum (PG) is an inflammatory dermatosis characterized by the rapid progression of a painful, necrolytic ulcer with an irregular and undermined border. The prevalence of PG in patients with Crohn’s disease (CD) has been estimated to be 0.7%. Here, we report a case that presented vario...

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Autores principales: Zhang, Heng, Sun, Yifang, Li, Kun, Zhang, Jianzhong, Chen, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375554/
https://www.ncbi.nlm.nih.gov/pubmed/35971452
http://dx.doi.org/10.2147/CCID.S374973
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author Zhang, Heng
Sun, Yifang
Li, Kun
Zhang, Jianzhong
Chen, Xue
author_facet Zhang, Heng
Sun, Yifang
Li, Kun
Zhang, Jianzhong
Chen, Xue
author_sort Zhang, Heng
collection PubMed
description Pyoderma gangrenosum (PG) is an inflammatory dermatosis characterized by the rapid progression of a painful, necrolytic ulcer with an irregular and undermined border. The prevalence of PG in patients with Crohn’s disease (CD) has been estimated to be 0.7%. Here, we report a case that presented various painful skin lesions, including erythema, vesicles, plaques, and ulcers, one week before the fourth infliximab infusion for CD. PG was diagnosed and the lesions subsided after a 390-mg ustekinumab infusion for one month. It suggests that different lesions of PG may occur concomitantly in CD patients, and the therapy should be re-evaluated on time.
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spelling pubmed-93755542022-08-14 Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient Zhang, Heng Sun, Yifang Li, Kun Zhang, Jianzhong Chen, Xue Clin Cosmet Investig Dermatol Case Report Pyoderma gangrenosum (PG) is an inflammatory dermatosis characterized by the rapid progression of a painful, necrolytic ulcer with an irregular and undermined border. The prevalence of PG in patients with Crohn’s disease (CD) has been estimated to be 0.7%. Here, we report a case that presented various painful skin lesions, including erythema, vesicles, plaques, and ulcers, one week before the fourth infliximab infusion for CD. PG was diagnosed and the lesions subsided after a 390-mg ustekinumab infusion for one month. It suggests that different lesions of PG may occur concomitantly in CD patients, and the therapy should be re-evaluated on time. Dove 2022-08-09 /pmc/articles/PMC9375554/ /pubmed/35971452 http://dx.doi.org/10.2147/CCID.S374973 Text en © 2022 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Zhang, Heng
Sun, Yifang
Li, Kun
Zhang, Jianzhong
Chen, Xue
Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient
title Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient
title_full Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient
title_fullStr Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient
title_full_unstemmed Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient
title_short Multiple Lesions at Different Stages of Pyoderma Gangrenosum in a Crohn’s Disease Patient
title_sort multiple lesions at different stages of pyoderma gangrenosum in a crohn’s disease patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375554/
https://www.ncbi.nlm.nih.gov/pubmed/35971452
http://dx.doi.org/10.2147/CCID.S374973
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