Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review

Exosomes can be released by a variety of cells and participate in intercellular communication in many physiological processes in the body. They can be used as carriers of cancer therapeutic drugs and have natural delivery capabilities. Some biologically active substances on exosomes, such as major h...

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Detalles Bibliográficos
Autores principales: Fang, Zhen, Ding, Yixuan, Xue, Zhigang, Li, Peijuan, Li, Jia, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375799/
https://www.ncbi.nlm.nih.gov/pubmed/35962862
http://dx.doi.org/10.1007/s12672-022-00539-5
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author Fang, Zhen
Ding, Yixuan
Xue, Zhigang
Li, Peijuan
Li, Jia
Li, Fei
author_facet Fang, Zhen
Ding, Yixuan
Xue, Zhigang
Li, Peijuan
Li, Jia
Li, Fei
author_sort Fang, Zhen
collection PubMed
description Exosomes can be released by a variety of cells and participate in intercellular communication in many physiological processes in the body. They can be used as carriers of cancer therapeutic drugs and have natural delivery capabilities. Some biologically active substances on exosomes, such as major histocompatibility complex (MHC), have been shown to be involved in exosome-mediated anticancer immune responses and have important regulatory effects on the immune system. Exosome-based drug delivery systems hold great promise in future cancer immunotherapy. However, there are still substantial challenges to be overcome in the clinical application of exosomes as drug carriers. This article reviews the biological characteristics of exosome drug delivery systems and their potential applications and challenges in cancer immunotherapy.
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spelling pubmed-93757992022-08-15 Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review Fang, Zhen Ding, Yixuan Xue, Zhigang Li, Peijuan Li, Jia Li, Fei Discov Oncol Review Exosomes can be released by a variety of cells and participate in intercellular communication in many physiological processes in the body. They can be used as carriers of cancer therapeutic drugs and have natural delivery capabilities. Some biologically active substances on exosomes, such as major histocompatibility complex (MHC), have been shown to be involved in exosome-mediated anticancer immune responses and have important regulatory effects on the immune system. Exosome-based drug delivery systems hold great promise in future cancer immunotherapy. However, there are still substantial challenges to be overcome in the clinical application of exosomes as drug carriers. This article reviews the biological characteristics of exosome drug delivery systems and their potential applications and challenges in cancer immunotherapy. Springer US 2022-08-13 /pmc/articles/PMC9375799/ /pubmed/35962862 http://dx.doi.org/10.1007/s12672-022-00539-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Fang, Zhen
Ding, Yixuan
Xue, Zhigang
Li, Peijuan
Li, Jia
Li, Fei
Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
title Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
title_full Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
title_fullStr Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
title_full_unstemmed Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
title_short Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
title_sort roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375799/
https://www.ncbi.nlm.nih.gov/pubmed/35962862
http://dx.doi.org/10.1007/s12672-022-00539-5
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