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Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent

PURPOSE: Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabelled ATMi to determine drug pharmacokinetics could assist patient selection in a m...

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Detalles Bibliográficos
Autores principales:	Fraser, Claudia Rose, Ajenjo, Javier, Veal, Mathew, Dias, Gemma Marie, Chan, Chung, O’Neill, Edward, Destro, Gianluca, Lau, Doreen, Pacelli, Anna, Gouverneur, Veronique, Hueting, Rebekka, Cornelissen, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375819/ https://www.ncbi.nlm.nih.gov/pubmed/35962885 http://dx.doi.org/10.1186/s13550-022-00920-z

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