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Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway

BACKGROUND: The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD). Presenilin-1 (PS1) mutations account for the most common causes of familial Alzheimer’s disease (FAD); however, wheth...

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Detalles Bibliográficos
Autores principales:	Chong, Cheong-Meng, Tan, Yuan, Tong, Jiaqi, Ke, Minjing, Zhang, Ke, Yan, Lingli, Cen, Xiaotong, Lu, Jia-Hong, Chen, Guobing, Su, Huanxing, Qin, Dajiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375916/ https://www.ncbi.nlm.nih.gov/pubmed/35965317 http://dx.doi.org/10.1186/s13578-022-00874-8

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