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Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study

BACKGROUND: We aimed to assess the efficacy of the injections of platelet rich plasma (PRP) for the treatment of severe dry eye disease (DED). RESULTS: In this retrospecitve interventional clinincal study, we included 28 eyes of 14 patients with severe DED who were diagnosed with Sjogren syndrome. E...

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Autores principales: Mohammed, Mai A., Allam, Ibrahim Y., Shaheen, Mohamed Shafik, Lazreg, Sihem, Doheim, Mohamed Fahmy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375917/
https://www.ncbi.nlm.nih.gov/pubmed/35964112
http://dx.doi.org/10.1186/s12886-022-02554-0
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author Mohammed, Mai A.
Allam, Ibrahim Y.
Shaheen, Mohamed Shafik
Lazreg, Sihem
Doheim, Mohamed Fahmy
author_facet Mohammed, Mai A.
Allam, Ibrahim Y.
Shaheen, Mohamed Shafik
Lazreg, Sihem
Doheim, Mohamed Fahmy
author_sort Mohammed, Mai A.
collection PubMed
description BACKGROUND: We aimed to assess the efficacy of the injections of platelet rich plasma (PRP) for the treatment of severe dry eye disease (DED). RESULTS: In this retrospecitve interventional clinincal study, we included 28 eyes of 14 patients with severe DED who were diagnosed with Sjogren syndrome. Each patient received unilateral lacrimal gland injection of PRP at days 0, 30, 60 and 90 days while the other eye served as control group who received preservative free eye drops. We objectively assessed parameters at baseline, 1 month, 2 months and 3 months including ocular surface analyzer (OSA) namely; noninvasive tear breakup times (NIBUT), tear meniscus height (TMH), lipid layer thickness (LLT) in addition to the Schirmer test I, corneal fluorescein staining (CFS) and meiboscore. The mean age was 43.4 ± .7.85 years. Comparing different parameters, baseline data showed non-significant difference between injected eye group and control group. After 1 and 3 months of follow up, there were significant differences between both groups regarding NITBUT, TMH, LLT, CFS and Schirmer test, with p <  0.001 in favor of PRP group. CONCLUSION: Injection of PRP in lacrimal gland is simple, safe, and effective technique in treatment of severe dry eye; proved by improvement of tear film parameters through subjective and objective assessment. Further studies are needed to standardize the technique and to confirm these results.
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spelling pubmed-93759172022-08-15 Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study Mohammed, Mai A. Allam, Ibrahim Y. Shaheen, Mohamed Shafik Lazreg, Sihem Doheim, Mohamed Fahmy BMC Ophthalmol Research BACKGROUND: We aimed to assess the efficacy of the injections of platelet rich plasma (PRP) for the treatment of severe dry eye disease (DED). RESULTS: In this retrospecitve interventional clinincal study, we included 28 eyes of 14 patients with severe DED who were diagnosed with Sjogren syndrome. Each patient received unilateral lacrimal gland injection of PRP at days 0, 30, 60 and 90 days while the other eye served as control group who received preservative free eye drops. We objectively assessed parameters at baseline, 1 month, 2 months and 3 months including ocular surface analyzer (OSA) namely; noninvasive tear breakup times (NIBUT), tear meniscus height (TMH), lipid layer thickness (LLT) in addition to the Schirmer test I, corneal fluorescein staining (CFS) and meiboscore. The mean age was 43.4 ± .7.85 years. Comparing different parameters, baseline data showed non-significant difference between injected eye group and control group. After 1 and 3 months of follow up, there were significant differences between both groups regarding NITBUT, TMH, LLT, CFS and Schirmer test, with p <  0.001 in favor of PRP group. CONCLUSION: Injection of PRP in lacrimal gland is simple, safe, and effective technique in treatment of severe dry eye; proved by improvement of tear film parameters through subjective and objective assessment. Further studies are needed to standardize the technique and to confirm these results. BioMed Central 2022-08-13 /pmc/articles/PMC9375917/ /pubmed/35964112 http://dx.doi.org/10.1186/s12886-022-02554-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Mohammed, Mai A.
Allam, Ibrahim Y.
Shaheen, Mohamed Shafik
Lazreg, Sihem
Doheim, Mohamed Fahmy
Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study
title Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study
title_full Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study
title_fullStr Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study
title_full_unstemmed Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study
title_short Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study
title_sort lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375917/
https://www.ncbi.nlm.nih.gov/pubmed/35964112
http://dx.doi.org/10.1186/s12886-022-02554-0
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