An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use

Nitrofurantoin is a commonly prescribed antibiotic for uncomplicated urinary tract infections. Despite a number of side effects, it is increasingly prescribed due to its low cost, high efficacy, and minimal antimicrobial resistance. One of the rare, however significant side effects of nitrofurantoin...

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Autores principales: Wonnacott, Stephen, Gala, Dhir, Shah, Mili, Kaul, Diksha, Kumar, Vikash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Family/General Practice
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375953/
https://www.ncbi.nlm.nih.gov/pubmed/35978742
http://dx.doi.org/10.7759/cureus.26882
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author Wonnacott, Stephen
Gala, Dhir
Shah, Mili
Kaul, Diksha
Kumar, Vikash
author_facet Wonnacott, Stephen
Gala, Dhir
Shah, Mili
Kaul, Diksha
Kumar, Vikash
author_sort Wonnacott, Stephen
collection PubMed
description Nitrofurantoin is a commonly prescribed antibiotic for uncomplicated urinary tract infections. Despite a number of side effects, it is increasingly prescribed due to its low cost, high efficacy, and minimal antimicrobial resistance. One of the rare, however significant side effects of nitrofurantoin is idiosyncratic drug-induced liver toxicity. It commonly presents with abdominal pain and elevated liver enzymes. Interestingly, it can cause either an acute or a chronic hepatitis-like syndrome that can be severe and lead to liver failure or cirrhosis. We present a case of a healthy 24-year-old female who presented with epigastric abdominal pain, which was found to be drug-induced liver injury (DILI) secondary to her recent nitrofurantoin use.
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spelling pubmed-93759532022-08-16 An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use Wonnacott, Stephen Gala, Dhir Shah, Mili Kaul, Diksha Kumar, Vikash Cureus Family/General Practice Nitrofurantoin is a commonly prescribed antibiotic for uncomplicated urinary tract infections. Despite a number of side effects, it is increasingly prescribed due to its low cost, high efficacy, and minimal antimicrobial resistance. One of the rare, however significant side effects of nitrofurantoin is idiosyncratic drug-induced liver toxicity. It commonly presents with abdominal pain and elevated liver enzymes. Interestingly, it can cause either an acute or a chronic hepatitis-like syndrome that can be severe and lead to liver failure or cirrhosis. We present a case of a healthy 24-year-old female who presented with epigastric abdominal pain, which was found to be drug-induced liver injury (DILI) secondary to her recent nitrofurantoin use. Cureus 2022-07-15 /pmc/articles/PMC9375953/ /pubmed/35978742 http://dx.doi.org/10.7759/cureus.26882 Text en Copyright © 2022, Wonnacott et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Wonnacott, Stephen
Gala, Dhir
Shah, Mili
Kaul, Diksha
Kumar, Vikash
An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use
title An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use
title_full An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use
title_fullStr An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use
title_full_unstemmed An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use
title_short An Unusual Case of Drug-Induced Liver Injury Secondary to Nitrofurantoin Use
title_sort unusual case of drug-induced liver injury secondary to nitrofurantoin use
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375953/
https://www.ncbi.nlm.nih.gov/pubmed/35978742
http://dx.doi.org/10.7759/cureus.26882
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