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A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia

BACKGROUND: The nature of the healthcare workers’ jobs standing at the frontline against the coronavirus disease 2019 (COVID-19) puts them at a higher risk of unknowingly contracting the disease and potentially contributing to the spread. This study aims to assess the overall positive seroconversion...

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Autores principales: Mushcab, Hayat, Al-Tawfiq, Jaffar A, Ghamdi, Mohammed, Babgi, Amani, Amir, Abdulrazack, Sheikh, Salwa S, Darwisheh, Adel, Alobaid, Abrar, Jebakumar, Arulanantham Zechariah, Qahtani, Saeed, Al Sagheir, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375977/
https://www.ncbi.nlm.nih.gov/pubmed/35974896
http://dx.doi.org/10.2147/IDR.S369755
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author Mushcab, Hayat
Al-Tawfiq, Jaffar A
Ghamdi, Mohammed
Babgi, Amani
Amir, Abdulrazack
Sheikh, Salwa S
Darwisheh, Adel
Alobaid, Abrar
Jebakumar, Arulanantham Zechariah
Qahtani, Saeed
Al Sagheir, Ahmed
author_facet Mushcab, Hayat
Al-Tawfiq, Jaffar A
Ghamdi, Mohammed
Babgi, Amani
Amir, Abdulrazack
Sheikh, Salwa S
Darwisheh, Adel
Alobaid, Abrar
Jebakumar, Arulanantham Zechariah
Qahtani, Saeed
Al Sagheir, Ahmed
author_sort Mushcab, Hayat
collection PubMed
description BACKGROUND: The nature of the healthcare workers’ jobs standing at the frontline against the coronavirus disease 2019 (COVID-19) puts them at a higher risk of unknowingly contracting the disease and potentially contributing to the spread. This study aims to assess the overall positive seroconversion prevalence of SARS-CoV-2. METHODS: This is a longitudinal cohort study of healthcare workers at Johns Hopkins Aramco Healthcare (JHAH). JHAH is a tertiary hospital located in Dhahran serving patients in several districts in the Eastern Province of Saudi Arabia. Participants were recruited between June and December 2020. Each participant had a serology blood test and completed the World Health Organization’s risk factor assessment questionnaire. RESULTS: This study included 682 participants working in JHAH, representing 15.7% of our population. Out of the 682 participants, 15.2% had a positive SARS-CoV-2 rt-PCR before taking part in the study. However, only 87 tested positive for SARS-CoV-2 antibodies, a prevalence of 12.7% of all participants. Out of the 87 positives for SARS-CoV-2 antibodies, 17 participants never tested positive for COVID-19 rt-PCR, a prevalence of 2.9%. Moreover, not properly using alcohol-based hand rub or soap and water after the risk of body fluid exposure and wearing personal protective equipment when indicated were found to be statistically significant to having a positive SARS-CoV-2 IgG assay. CONCLUSION: Positive seroconversion rate was considerably low during the first wave of COVID-19 amongst JHAH’s healthcare workers and similar to other healthcare organizations in Saudi Arabia. Seropositivity correlated significantly with following infection prevention and control recommendations. CLINICALTRIALS.GOV IDENTIFIER: NCT04469647.
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spelling pubmed-93759772022-08-15 A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia Mushcab, Hayat Al-Tawfiq, Jaffar A Ghamdi, Mohammed Babgi, Amani Amir, Abdulrazack Sheikh, Salwa S Darwisheh, Adel Alobaid, Abrar Jebakumar, Arulanantham Zechariah Qahtani, Saeed Al Sagheir, Ahmed Infect Drug Resist Original Research BACKGROUND: The nature of the healthcare workers’ jobs standing at the frontline against the coronavirus disease 2019 (COVID-19) puts them at a higher risk of unknowingly contracting the disease and potentially contributing to the spread. This study aims to assess the overall positive seroconversion prevalence of SARS-CoV-2. METHODS: This is a longitudinal cohort study of healthcare workers at Johns Hopkins Aramco Healthcare (JHAH). JHAH is a tertiary hospital located in Dhahran serving patients in several districts in the Eastern Province of Saudi Arabia. Participants were recruited between June and December 2020. Each participant had a serology blood test and completed the World Health Organization’s risk factor assessment questionnaire. RESULTS: This study included 682 participants working in JHAH, representing 15.7% of our population. Out of the 682 participants, 15.2% had a positive SARS-CoV-2 rt-PCR before taking part in the study. However, only 87 tested positive for SARS-CoV-2 antibodies, a prevalence of 12.7% of all participants. Out of the 87 positives for SARS-CoV-2 antibodies, 17 participants never tested positive for COVID-19 rt-PCR, a prevalence of 2.9%. Moreover, not properly using alcohol-based hand rub or soap and water after the risk of body fluid exposure and wearing personal protective equipment when indicated were found to be statistically significant to having a positive SARS-CoV-2 IgG assay. CONCLUSION: Positive seroconversion rate was considerably low during the first wave of COVID-19 amongst JHAH’s healthcare workers and similar to other healthcare organizations in Saudi Arabia. Seropositivity correlated significantly with following infection prevention and control recommendations. CLINICALTRIALS.GOV IDENTIFIER: NCT04469647. Dove 2022-08-10 /pmc/articles/PMC9375977/ /pubmed/35974896 http://dx.doi.org/10.2147/IDR.S369755 Text en © 2022 Mushcab et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Mushcab, Hayat
Al-Tawfiq, Jaffar A
Ghamdi, Mohammed
Babgi, Amani
Amir, Abdulrazack
Sheikh, Salwa S
Darwisheh, Adel
Alobaid, Abrar
Jebakumar, Arulanantham Zechariah
Qahtani, Saeed
Al Sagheir, Ahmed
A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia
title A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia
title_full A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia
title_fullStr A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia
title_full_unstemmed A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia
title_short A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia
title_sort cohort study of seroprevalence of antibodies against sars-cov-2 infection among healthcare workers at a tertiary hospital in saudi arabia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375977/
https://www.ncbi.nlm.nih.gov/pubmed/35974896
http://dx.doi.org/10.2147/IDR.S369755
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