Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer

Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive tumor microenvironment. Here we show that changes in chondroitin sulfate (CS), a major glycosaminoglycan component of the tumor cell glycocalyx and extr...

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Detalles Bibliográficos
Autores principales: Al-Nakouzi, Nader, Wang, Chris Kedong, Oo, Htoo Zarni, Nelepcu, Irina, Lallous, Nada, Spliid, Charlotte B., Khazamipour, Nastaran, Lo, Joey, Truong, Sarah, Collins, Colin, Hui, Desmond, Esfandnia, Shaghayegh, Adomat, Hans, Clausen, Thomas Mandel, Gustavsson, Tobias, Choudhary, Swati, Dagil, Robert, Corey, Eva, Wang, Yuzhuo, Chauchereau, Anne, Fazli, Ladan, Esko, Jeffrey D., Salanti, Ali, Nelson, Peter S., Gleave, Martin E., Daugaard, Mads
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376089/
https://www.ncbi.nlm.nih.gov/pubmed/35963852
http://dx.doi.org/10.1038/s41467-022-32530-7

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