XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

Cells employ global genome nucleotide excision repair (GGR) to eliminate a broad spectrum of DNA lesions, including those induced by UV light. The lesion-recognition factor XPC initiates repair of helix-destabilizing DNA lesions, but binds poorly to lesions such as CPDs that do not destabilize DNA....

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Detalles Bibliográficos
Autores principales: Blessing, Charlotte, Apelt, Katja, van den Heuvel, Diana, Gonzalez-Leal, Claudia, Rother, Magdalena B., van der Woude, Melanie, González-Prieto, Román, Yifrach, Adi, Parnas, Avital, Shah, Rashmi G., Kuo, Tia Tyrsett, Boer, Daphne E. C., Cai, Jin, Kragten, Angela, Kim, Hyun-Suk, Schärer, Orlando D., Vertegaal, Alfred C. O., Shah, Girish M., Adar, Sheera, Lans, Hannes, van Attikum, Haico, Ladurner, Andreas G., Luijsterburg, Martijn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376112/
https://www.ncbi.nlm.nih.gov/pubmed/35963869
http://dx.doi.org/10.1038/s41467-022-31820-4

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