CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

[Image: see text] Introduction: B lymphocyte-induced maturation protein 1 (BLIMP1) encoded by the positive regulatory domain 1 gene (PRDM1), is a key regulator in T cell differentiation in mouse models. BLIMP1-deficiency results in a lower effector phenotype and a higher memory phenotype. Methods: I...

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Detalles Bibliográficos
Autores principales: Azadbakht, Mohammad, Sayadmanesh, Ali, Nazer, Naghme, Ahmadi, Amirhossein, Hemmati, Sara, Mohammadzade, Hoda, Ebrahimi, Marzieh, Baharvand, Hossein, Khalaj, Babak, Aghamaali, Mahmoud Reza, Basiri, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences (TUOMS Publishing Group) 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376159/
https://www.ncbi.nlm.nih.gov/pubmed/35975204
http://dx.doi.org/10.34172/bi.2021.23522

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