Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide

A 74-year-old woman with type 2 diabetes mellitus presented with nausea and abdomen distension. Four days prior, liraglutide 0.6 mg had been commenced. An abdominal computed tomography scan revealed gastric dilatation without mechanical obstruction which clinically suggested gastroparesis (GP). Her...

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Detalles Bibliográficos
Autores principales: Ishihara, Yo, Nishiguchi, Sho, Branch, Joel, Tanaka, Eri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376210/
https://www.ncbi.nlm.nih.gov/pubmed/35983392
http://dx.doi.org/10.7759/cureus.26916
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author Ishihara, Yo
Nishiguchi, Sho
Branch, Joel
Tanaka, Eri
author_facet Ishihara, Yo
Nishiguchi, Sho
Branch, Joel
Tanaka, Eri
author_sort Ishihara, Yo
collection PubMed
description A 74-year-old woman with type 2 diabetes mellitus presented with nausea and abdomen distension. Four days prior, liraglutide 0.6 mg had been commenced. An abdominal computed tomography scan revealed gastric dilatation without mechanical obstruction which clinically suggested gastroparesis (GP). Her symptoms resolved after liraglutide discontinuation. A gastroscopy revealed reflux esophagitis. Taken together, GP may have developed along with reflux esophagitis due to liraglutide administration. Liraglutide’s action inhibits gastric motility. Physicians should be cognizant of the side effects of GLP-1 agonists even in low dose in patients who have gastric emptying symptoms suggesting GP.
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spelling pubmed-93762102022-08-17 Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide Ishihara, Yo Nishiguchi, Sho Branch, Joel Tanaka, Eri Cureus Endocrinology/Diabetes/Metabolism A 74-year-old woman with type 2 diabetes mellitus presented with nausea and abdomen distension. Four days prior, liraglutide 0.6 mg had been commenced. An abdominal computed tomography scan revealed gastric dilatation without mechanical obstruction which clinically suggested gastroparesis (GP). Her symptoms resolved after liraglutide discontinuation. A gastroscopy revealed reflux esophagitis. Taken together, GP may have developed along with reflux esophagitis due to liraglutide administration. Liraglutide’s action inhibits gastric motility. Physicians should be cognizant of the side effects of GLP-1 agonists even in low dose in patients who have gastric emptying symptoms suggesting GP. Cureus 2022-07-16 /pmc/articles/PMC9376210/ /pubmed/35983392 http://dx.doi.org/10.7759/cureus.26916 Text en Copyright © 2022, Ishihara et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Ishihara, Yo
Nishiguchi, Sho
Branch, Joel
Tanaka, Eri
Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide
title Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide
title_full Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide
title_fullStr Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide
title_full_unstemmed Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide
title_short Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide
title_sort suspected gastroparesis with concurrent gastroesophageal reflux disease induced by low-dose liraglutide
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376210/
https://www.ncbi.nlm.nih.gov/pubmed/35983392
http://dx.doi.org/10.7759/cureus.26916
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