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Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells
Interleukin-33 (IL-33) is a pleiotropic cytokine linked to various immune cells in the innate and adaptive immune systems. Recent studies of the effects of IL-33 on immune cells are beginning to reveal its regulatory mechanisms at the levels of cellular metabolism and epigenetic modifications. In re...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376228/ https://www.ncbi.nlm.nih.gov/pubmed/35979357 http://dx.doi.org/10.3389/fimmu.2022.900826 |
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author | Lin, Jian Liu, Jiyun Ma, Rui Hao, Jie Liang, Yan Zhao, Junjie Zhang, Ailing Meng, Haiyang Lu, Jingli |
author_facet | Lin, Jian Liu, Jiyun Ma, Rui Hao, Jie Liang, Yan Zhao, Junjie Zhang, Ailing Meng, Haiyang Lu, Jingli |
author_sort | Lin, Jian |
collection | PubMed |
description | Interleukin-33 (IL-33) is a pleiotropic cytokine linked to various immune cells in the innate and adaptive immune systems. Recent studies of the effects of IL-33 on immune cells are beginning to reveal its regulatory mechanisms at the levels of cellular metabolism and epigenetic modifications. In response to IL-33 stimulation, these programs are intertwined with transcriptional programs, ultimately determining the fate of immune cells. Understanding these specific molecular events will help to explain the complex role of IL-33 in immune cells, thereby guiding the development of new strategies for immune intervention. Here, we highlight recent findings that reveal how IL-33, acting as an intracellular nuclear factor or an extracellular cytokine, alters metabolic checkpoints and cellular metabolism, which coordinately contribute to cell growth and function. We also discuss recent studies supporting the role of IL-33 in epigenetic alterations and speculate about the mechanisms underlying this relationship. |
format | Online Article Text |
id | pubmed-9376228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93762282022-08-16 Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells Lin, Jian Liu, Jiyun Ma, Rui Hao, Jie Liang, Yan Zhao, Junjie Zhang, Ailing Meng, Haiyang Lu, Jingli Front Immunol Immunology Interleukin-33 (IL-33) is a pleiotropic cytokine linked to various immune cells in the innate and adaptive immune systems. Recent studies of the effects of IL-33 on immune cells are beginning to reveal its regulatory mechanisms at the levels of cellular metabolism and epigenetic modifications. In response to IL-33 stimulation, these programs are intertwined with transcriptional programs, ultimately determining the fate of immune cells. Understanding these specific molecular events will help to explain the complex role of IL-33 in immune cells, thereby guiding the development of new strategies for immune intervention. Here, we highlight recent findings that reveal how IL-33, acting as an intracellular nuclear factor or an extracellular cytokine, alters metabolic checkpoints and cellular metabolism, which coordinately contribute to cell growth and function. We also discuss recent studies supporting the role of IL-33 in epigenetic alterations and speculate about the mechanisms underlying this relationship. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9376228/ /pubmed/35979357 http://dx.doi.org/10.3389/fimmu.2022.900826 Text en Copyright © 2022 Lin, Liu, Ma, Hao, Liang, Zhao, Zhang, Meng and Lu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lin, Jian Liu, Jiyun Ma, Rui Hao, Jie Liang, Yan Zhao, Junjie Zhang, Ailing Meng, Haiyang Lu, Jingli Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells |
title | Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells |
title_full | Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells |
title_fullStr | Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells |
title_full_unstemmed | Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells |
title_short | Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells |
title_sort | interleukin-33: metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376228/ https://www.ncbi.nlm.nih.gov/pubmed/35979357 http://dx.doi.org/10.3389/fimmu.2022.900826 |
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