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Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy

Immunogenic cell death (ICD) promotes the immune antitumor response via releasing damage-associated molecular patterns (DAMPs) from dying tumor cells. The induction of autophagy improves the efficacy of multiple immunogenic chemotherapies. Here, we show that piceatannol, a dietary phenolic compound...

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Autores principales: Wang, Shuang, Wang, Guangsuo, Wu, Weiqing, Xu, Zhenglei, Yang, Jing, Cao, Min, Wang, Qi, Wang, Jigang, Yang, Chuanbin, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376326/
https://www.ncbi.nlm.nih.gov/pubmed/35979349
http://dx.doi.org/10.3389/fimmu.2022.968686
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author Wang, Shuang
Wang, Guangsuo
Wu, Weiqing
Xu, Zhenglei
Yang, Jing
Cao, Min
Wang, Qi
Wang, Jigang
Yang, Chuanbin
Zhang, Wei
author_facet Wang, Shuang
Wang, Guangsuo
Wu, Weiqing
Xu, Zhenglei
Yang, Jing
Cao, Min
Wang, Qi
Wang, Jigang
Yang, Chuanbin
Zhang, Wei
author_sort Wang, Shuang
collection PubMed
description Immunogenic cell death (ICD) promotes the immune antitumor response via releasing damage-associated molecular patterns (DAMPs) from dying tumor cells. The induction of autophagy improves the efficacy of multiple immunogenic chemotherapies. Here, we show that piceatannol, a dietary phenolic compound that is widely distributed in multiple fruits and vegetables such as grapes, blueberries, and mushrooms, induces autophagy and enhances oxaliplatin (OXA)-induced anticancer immune response. Specifically, piceatannol enhanced OXA-induced release of DAMPs, several key hallmarks of ICD including ATP release, cell surface exposure of calreticulin, and high-mobility group box 1 (HMGB1) release. Mechanistically, piceatannol promoted autophagy via activating TFEB/TFE3, two key transcription factors of the autophagy-lysosome pathway, and inhibiting autophagy attenuated piceatannol plus OXA-induced ATP release. Furthermore, piceatannol induced endoplasmic reticulum stress, which is critical for its role in enhancing OXA-induced cell surface exposure of calreticulin, another key hallmark of ICD. Consistently, the combination of piceatannol with OXA promoted the anticancer effects in immunocompetent mice. Taken together, our results indicate the importance and great potential of dietary piceatannol in cancer immunotherapy. Therefore, piceatannol may be used as an ICD enhancer that improves the efficacy of chemotherapeutics such as OXA in cancer treatment with minimized toxicity.
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spelling pubmed-93763262022-08-16 Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy Wang, Shuang Wang, Guangsuo Wu, Weiqing Xu, Zhenglei Yang, Jing Cao, Min Wang, Qi Wang, Jigang Yang, Chuanbin Zhang, Wei Front Immunol Immunology Immunogenic cell death (ICD) promotes the immune antitumor response via releasing damage-associated molecular patterns (DAMPs) from dying tumor cells. The induction of autophagy improves the efficacy of multiple immunogenic chemotherapies. Here, we show that piceatannol, a dietary phenolic compound that is widely distributed in multiple fruits and vegetables such as grapes, blueberries, and mushrooms, induces autophagy and enhances oxaliplatin (OXA)-induced anticancer immune response. Specifically, piceatannol enhanced OXA-induced release of DAMPs, several key hallmarks of ICD including ATP release, cell surface exposure of calreticulin, and high-mobility group box 1 (HMGB1) release. Mechanistically, piceatannol promoted autophagy via activating TFEB/TFE3, two key transcription factors of the autophagy-lysosome pathway, and inhibiting autophagy attenuated piceatannol plus OXA-induced ATP release. Furthermore, piceatannol induced endoplasmic reticulum stress, which is critical for its role in enhancing OXA-induced cell surface exposure of calreticulin, another key hallmark of ICD. Consistently, the combination of piceatannol with OXA promoted the anticancer effects in immunocompetent mice. Taken together, our results indicate the importance and great potential of dietary piceatannol in cancer immunotherapy. Therefore, piceatannol may be used as an ICD enhancer that improves the efficacy of chemotherapeutics such as OXA in cancer treatment with minimized toxicity. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9376326/ /pubmed/35979349 http://dx.doi.org/10.3389/fimmu.2022.968686 Text en Copyright © 2022 Wang, Wang, Wu, Xu, Yang, Cao, Wang, Wang, Yang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Shuang
Wang, Guangsuo
Wu, Weiqing
Xu, Zhenglei
Yang, Jing
Cao, Min
Wang, Qi
Wang, Jigang
Yang, Chuanbin
Zhang, Wei
Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
title Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
title_full Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
title_fullStr Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
title_full_unstemmed Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
title_short Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
title_sort autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376326/
https://www.ncbi.nlm.nih.gov/pubmed/35979349
http://dx.doi.org/10.3389/fimmu.2022.968686
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