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CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro

Dendritic cell (DC)-based immunotherapy has increased interest among anti-cancer immunotherapies. Nevertheless, the immunosuppressive mechanisms in the tumor milieu, e.g., inhibitory immune checkpoint molecules, have been implicated in diminishing the efficacy of DC-mediated anti-tumoral immune resp...

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Detalles Bibliográficos
Autores principales:	Ghorbaninezhad, Farid, Masoumi, Javad, Bakhshivand, Mohammad, Baghbanzadeh, Amir, Mokhtarzadeh, Ahad, Kazemi, Tohid, Aghebati-Maleki, Leili, Shotorbani, Siamak Sandoghchian, Jafarlou, Mahdi, Brunetti, Oronzo, Santarpia, Mariacarmela, Baradaran, Behzad, Silvestris, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376327/ https://www.ncbi.nlm.nih.gov/pubmed/35979362 http://dx.doi.org/10.3389/fimmu.2022.931316

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