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Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants

Essential oils have attracted wide attention in recent years due to their extensive applications in natural functional ingredients, pharmaceutical preparations, biomedical products, and the cosmetics industry. In this study, the chemical compositions and biological activities of essential oils extra...

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Autores principales: Sun, Jiahui, Sun, Peipei, Kang, Chuanzhi, Zhang, Lanyue, Guo, Lanping, Kou, Yaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376358/
https://www.ncbi.nlm.nih.gov/pubmed/35979072
http://dx.doi.org/10.3389/fpls.2022.919294
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author Sun, Jiahui
Sun, Peipei
Kang, Chuanzhi
Zhang, Lanyue
Guo, Lanping
Kou, Yaping
author_facet Sun, Jiahui
Sun, Peipei
Kang, Chuanzhi
Zhang, Lanyue
Guo, Lanping
Kou, Yaping
author_sort Sun, Jiahui
collection PubMed
description Essential oils have attracted wide attention in recent years due to their extensive applications in natural functional ingredients, pharmaceutical preparations, biomedical products, and the cosmetics industry. In this study, the chemical compositions and biological activities of essential oils extracted from six Lamiaceae herbs, including Pogostemon cablin (Blanco) Benth. (PCEO), Perilla frutescens (L.) Britton (PFEO), Salvia japonica Thunb. (SJEO), Rosmarinus officinalis L. (ROEO), Lavandula angustifolia Mill. (LAEO), and Agastache rugosa (Fisch. & C. A. Mey.) Kuntze (AREO), were determined and analyzed. A total of 167 components were identified from the six essential oils by GC-MS analysis, with 35, 24, 47, 46, 54, and 37 components in PCEO, PFEO, SJEO, ROEO, LAEO, and AREO, respectively. Hierarchical cluster analysis of chemical compositions showed that the composition of the six essential oils was significantly different in content, and they were clearly divided into six classes. However, all of these six essential oils exhibited promising anti-inflammatory activity by inhibiting the expression of interleukin-1, interleukin-6, tumor necrosis factor-α, and cyclooxygenase-2 in rats with adjuvant arthritis, among which PFEO had the best performance. In addition, the six essential oils displayed significant cytotoxicity on B16 (IC(50) = 86.91–228.91 μg/mL) and LNCaP cell lines (IC(50) = 116.4–189.63 μg/mL). Meanwhile, all of them presented satisfactory antioxidant activity (IC(50) = 4.88–13.89 μg/mL) compared with Trolox C (IC(50) = 13.83 μg/mL), and SJEO (IC(50) = 7.93 μg/mL) served as an optimal candidate natural antioxidant by DPPH assay. Taken together, these results indicate that the six Lamiaceae essential oils manifest excellent and diverse biological activities, enabling them to be used as perfect natural functional ingredients in antioxidant, antitumor, or anti-arthritic drugs. This study provides more references for pharmaphylogeny research and drug discovery from folk medicinal plants.
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spelling pubmed-93763582022-08-16 Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants Sun, Jiahui Sun, Peipei Kang, Chuanzhi Zhang, Lanyue Guo, Lanping Kou, Yaping Front Plant Sci Plant Science Essential oils have attracted wide attention in recent years due to their extensive applications in natural functional ingredients, pharmaceutical preparations, biomedical products, and the cosmetics industry. In this study, the chemical compositions and biological activities of essential oils extracted from six Lamiaceae herbs, including Pogostemon cablin (Blanco) Benth. (PCEO), Perilla frutescens (L.) Britton (PFEO), Salvia japonica Thunb. (SJEO), Rosmarinus officinalis L. (ROEO), Lavandula angustifolia Mill. (LAEO), and Agastache rugosa (Fisch. & C. A. Mey.) Kuntze (AREO), were determined and analyzed. A total of 167 components were identified from the six essential oils by GC-MS analysis, with 35, 24, 47, 46, 54, and 37 components in PCEO, PFEO, SJEO, ROEO, LAEO, and AREO, respectively. Hierarchical cluster analysis of chemical compositions showed that the composition of the six essential oils was significantly different in content, and they were clearly divided into six classes. However, all of these six essential oils exhibited promising anti-inflammatory activity by inhibiting the expression of interleukin-1, interleukin-6, tumor necrosis factor-α, and cyclooxygenase-2 in rats with adjuvant arthritis, among which PFEO had the best performance. In addition, the six essential oils displayed significant cytotoxicity on B16 (IC(50) = 86.91–228.91 μg/mL) and LNCaP cell lines (IC(50) = 116.4–189.63 μg/mL). Meanwhile, all of them presented satisfactory antioxidant activity (IC(50) = 4.88–13.89 μg/mL) compared with Trolox C (IC(50) = 13.83 μg/mL), and SJEO (IC(50) = 7.93 μg/mL) served as an optimal candidate natural antioxidant by DPPH assay. Taken together, these results indicate that the six Lamiaceae essential oils manifest excellent and diverse biological activities, enabling them to be used as perfect natural functional ingredients in antioxidant, antitumor, or anti-arthritic drugs. This study provides more references for pharmaphylogeny research and drug discovery from folk medicinal plants. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9376358/ /pubmed/35979072 http://dx.doi.org/10.3389/fpls.2022.919294 Text en Copyright © 2022 Sun, Sun, Kang, Zhang, Guo and Kou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Sun, Jiahui
Sun, Peipei
Kang, Chuanzhi
Zhang, Lanyue
Guo, Lanping
Kou, Yaping
Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants
title Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants
title_full Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants
title_fullStr Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants
title_full_unstemmed Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants
title_short Chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants
title_sort chemical composition and biological activities of essential oils from six lamiaceae folk medicinal plants
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376358/
https://www.ncbi.nlm.nih.gov/pubmed/35979072
http://dx.doi.org/10.3389/fpls.2022.919294
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