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Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet
Obesity induced by a high-fat diet (HFD) is an increasing global health problem, leading to many metabolic syndromes. As the emerging food additive rich in tea polyphenols, theanine, caffeine, and so on, matcha green tea has gained more and more popularity for its outstanding potential in ameliorati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376390/ https://www.ncbi.nlm.nih.gov/pubmed/35978960 http://dx.doi.org/10.3389/fnut.2022.931060 |
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author | Wang, Yuefei Yu, Yueer Ding, Lejia Xu, Ping Zhou, Jihong |
author_facet | Wang, Yuefei Yu, Yueer Ding, Lejia Xu, Ping Zhou, Jihong |
author_sort | Wang, Yuefei |
collection | PubMed |
description | Obesity induced by a high-fat diet (HFD) is an increasing global health problem, leading to many metabolic syndromes. As the emerging food additive rich in tea polyphenols, theanine, caffeine, and so on, matcha green tea has gained more and more popularity for its outstanding potential in ameliorating metabolic disorders. This study investigated the composition and antioxidant activity of matcha green tea and further explored its effects on gut–liver axis homeostasis in an HFD-induced obese mouse model. Male (7–8 weeks old) C57BL/6J mice were divided into four groups with the following dietary supplementation for 8 weeks: a normal chow diet (NCD), a normal chow diet+1.0% matcha (NCM), a high-fat diet (HFD), and a high-fat diet+1.0% matcha (HFM). The results demonstrated that matcha green tea ameliorated the development of obesity, lipid accumulation, and hepatic steatosis induced by HFD. Subsequently, dietary matcha supplementation restored the alterations in fecal bile acid profile and gut microbial composition. Meanwhile, the levels of mRNA expression in hepatocytes demonstrated that matcha intervention made significant regulatory on the multiple metabolic pathways of hosts involved in glucose, lipid, and bile acid metabolism. These findings present new evidence for matcha green tea as an effective nutritional strategy to mitigate obesity and relevant metabolic disorders through the gut–liver axis. |
format | Online Article Text |
id | pubmed-9376390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93763902022-08-16 Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet Wang, Yuefei Yu, Yueer Ding, Lejia Xu, Ping Zhou, Jihong Front Nutr Nutrition Obesity induced by a high-fat diet (HFD) is an increasing global health problem, leading to many metabolic syndromes. As the emerging food additive rich in tea polyphenols, theanine, caffeine, and so on, matcha green tea has gained more and more popularity for its outstanding potential in ameliorating metabolic disorders. This study investigated the composition and antioxidant activity of matcha green tea and further explored its effects on gut–liver axis homeostasis in an HFD-induced obese mouse model. Male (7–8 weeks old) C57BL/6J mice were divided into four groups with the following dietary supplementation for 8 weeks: a normal chow diet (NCD), a normal chow diet+1.0% matcha (NCM), a high-fat diet (HFD), and a high-fat diet+1.0% matcha (HFM). The results demonstrated that matcha green tea ameliorated the development of obesity, lipid accumulation, and hepatic steatosis induced by HFD. Subsequently, dietary matcha supplementation restored the alterations in fecal bile acid profile and gut microbial composition. Meanwhile, the levels of mRNA expression in hepatocytes demonstrated that matcha intervention made significant regulatory on the multiple metabolic pathways of hosts involved in glucose, lipid, and bile acid metabolism. These findings present new evidence for matcha green tea as an effective nutritional strategy to mitigate obesity and relevant metabolic disorders through the gut–liver axis. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9376390/ /pubmed/35978960 http://dx.doi.org/10.3389/fnut.2022.931060 Text en Copyright © 2022 Wang, Yu, Ding, Xu and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Wang, Yuefei Yu, Yueer Ding, Lejia Xu, Ping Zhou, Jihong Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet |
title | Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet |
title_full | Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet |
title_fullStr | Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet |
title_full_unstemmed | Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet |
title_short | Matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet |
title_sort | matcha green tea targets the gut–liver axis to alleviate obesity and metabolic disorders induced by a high-fat diet |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376390/ https://www.ncbi.nlm.nih.gov/pubmed/35978960 http://dx.doi.org/10.3389/fnut.2022.931060 |
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