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Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation

Extracellular β-amyloid (Aβ) deposition and intraneuronal phosphorylated-tau (pTau) accumulation are the hallmark lesions of Alzheimer’s disease (AD). Recently, “sorfra” plaques, named for the extracellular deposition of sortilin c-terminal fragments, are reported as a new AD-related proteopathy, wh...

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Detalles Bibliográficos
Autores principales:	Jiang, Juan, Yang, Chen, Ai, Jia-Qi, Zhang, Qi-Lei, Cai, Xiao-Lu, Tu, Tian, Wan, Lily, Wang, Xiao-Sheng, Wang, Hui, Pan, Aihua, Manavis, Jim, Gai, Wei-Ping, Che, Chong, Tu, Ewen, Wang, Xiao-Ping, Li, Zhen-Yan, Yan, Xiao-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376392/ https://www.ncbi.nlm.nih.gov/pubmed/35978952 http://dx.doi.org/10.3389/fnagi.2022.926904

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