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Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study

Light flash and odor during radiation therapy are well-known phenomena, but the details are poorly understood, particularly in pediatric patients. Therefore, we conducted a prospective observational study of these events in pediatric patients (age ≤20 years old) who received radiotherapy at our cent...

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Autores principales: Mizumoto, Masashi, Oshiro, Yoshiko, Miyamoto, Toshio, Sumiya, Taisuke, Baba, Keiichiro, Murakami, Motohiro, Shimizu, Shosei, Iizumi, Takashi, Saito, Takashi, Makishima, Hirokazu, Numajiri, Haruko, Nakai, Kei, Okumura, Toshiyuki, Maruo, Kazushi, Sakae, Takeji, Sakurai, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376462/
https://www.ncbi.nlm.nih.gov/pubmed/35978807
http://dx.doi.org/10.3389/fonc.2022.863260
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author Mizumoto, Masashi
Oshiro, Yoshiko
Miyamoto, Toshio
Sumiya, Taisuke
Baba, Keiichiro
Murakami, Motohiro
Shimizu, Shosei
Iizumi, Takashi
Saito, Takashi
Makishima, Hirokazu
Numajiri, Haruko
Nakai, Kei
Okumura, Toshiyuki
Maruo, Kazushi
Sakae, Takeji
Sakurai, Hideyuki
author_facet Mizumoto, Masashi
Oshiro, Yoshiko
Miyamoto, Toshio
Sumiya, Taisuke
Baba, Keiichiro
Murakami, Motohiro
Shimizu, Shosei
Iizumi, Takashi
Saito, Takashi
Makishima, Hirokazu
Numajiri, Haruko
Nakai, Kei
Okumura, Toshiyuki
Maruo, Kazushi
Sakae, Takeji
Sakurai, Hideyuki
author_sort Mizumoto, Masashi
collection PubMed
description Light flash and odor during radiation therapy are well-known phenomena, but the details are poorly understood, particularly in pediatric patients. Therefore, we conducted a prospective observational study of these events in pediatric patients (age ≤20 years old) who received radiotherapy at our center from January 2019 to November 2021. Light flash and odor were evaluated using a patient-reported checklist including the presence, strength, and duration of the phenomenon, and color of light or type of odor. 53 patients who received proton therapy (n=47) and photon radiotherapy (n=6) were enrolled in this study. The median age of the patients was 10, ranged from 5 to 20. The patients who was able to see the light flash was 4, and all of them received retina irradiation. This was equivalent to 57% of the patients who received radiotherapy to retina (n=7). The light was bright and colored mainly blue and purple, which seemed to be consistent with Cherenkov light. Odor was sensed by 9 (17%) patients, and seven patients of the 9 received nasal cavity irradiation. This was equivalent to 41% of the patients who received nasal cavity irradiation (n=17). Other 2 patients received proton therapy to brain tumor. The odors were mainly described as plastic, burnt and disinfectant, which may be caused by ozone generated during irradiation. These data suggest that pediatric patients with retinal and nasal cavity irradiation frequently sense light flashes or odor. So adequate care is necessary so that these patients are not worried about this phenomenon.
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spelling pubmed-93764622022-08-16 Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study Mizumoto, Masashi Oshiro, Yoshiko Miyamoto, Toshio Sumiya, Taisuke Baba, Keiichiro Murakami, Motohiro Shimizu, Shosei Iizumi, Takashi Saito, Takashi Makishima, Hirokazu Numajiri, Haruko Nakai, Kei Okumura, Toshiyuki Maruo, Kazushi Sakae, Takeji Sakurai, Hideyuki Front Oncol Oncology Light flash and odor during radiation therapy are well-known phenomena, but the details are poorly understood, particularly in pediatric patients. Therefore, we conducted a prospective observational study of these events in pediatric patients (age ≤20 years old) who received radiotherapy at our center from January 2019 to November 2021. Light flash and odor were evaluated using a patient-reported checklist including the presence, strength, and duration of the phenomenon, and color of light or type of odor. 53 patients who received proton therapy (n=47) and photon radiotherapy (n=6) were enrolled in this study. The median age of the patients was 10, ranged from 5 to 20. The patients who was able to see the light flash was 4, and all of them received retina irradiation. This was equivalent to 57% of the patients who received radiotherapy to retina (n=7). The light was bright and colored mainly blue and purple, which seemed to be consistent with Cherenkov light. Odor was sensed by 9 (17%) patients, and seven patients of the 9 received nasal cavity irradiation. This was equivalent to 41% of the patients who received nasal cavity irradiation (n=17). Other 2 patients received proton therapy to brain tumor. The odors were mainly described as plastic, burnt and disinfectant, which may be caused by ozone generated during irradiation. These data suggest that pediatric patients with retinal and nasal cavity irradiation frequently sense light flashes or odor. So adequate care is necessary so that these patients are not worried about this phenomenon. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9376462/ /pubmed/35978807 http://dx.doi.org/10.3389/fonc.2022.863260 Text en Copyright © 2022 Mizumoto, Oshiro, Miyamoto, Sumiya, Baba, Murakami, Shimizu, Iizumi, Saito, Makishima, Numajiri, Nakai, Okumura, Maruo, Sakae and Sakurai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Mizumoto, Masashi
Oshiro, Yoshiko
Miyamoto, Toshio
Sumiya, Taisuke
Baba, Keiichiro
Murakami, Motohiro
Shimizu, Shosei
Iizumi, Takashi
Saito, Takashi
Makishima, Hirokazu
Numajiri, Haruko
Nakai, Kei
Okumura, Toshiyuki
Maruo, Kazushi
Sakae, Takeji
Sakurai, Hideyuki
Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study
title Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study
title_full Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study
title_fullStr Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study
title_full_unstemmed Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study
title_short Light flash and odor during proton beam therapy for pediatric patients: a prospective observational study
title_sort light flash and odor during proton beam therapy for pediatric patients: a prospective observational study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376462/
https://www.ncbi.nlm.nih.gov/pubmed/35978807
http://dx.doi.org/10.3389/fonc.2022.863260
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