Cargando…

The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing

Adult T-cell leukemia/lymphoma (ATL) is a T-cell lymphoproliferative neoplasm caused by the human T-cell leukemia virus type 1 (HTLV-1). Two viral proteins, Tax-1 and HBZ play important roles in HTLV-1 infectivity and in HTLV-1-associated pathologies by altering key pathways of cell homeostasis. How...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shallak, Mariam, Alberio, Tiziana, Fasano, Mauro, Monti, Maria, Iacobucci, Ilaria, Ladet, Julien, Mortreux, Franck, Accolla, Roberto S., Forlani, Greta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376625/ https://www.ncbi.nlm.nih.gov/pubmed/35979358 http://dx.doi.org/10.3389/fimmu.2022.939863

Ejemplares similares

Localization, quantification and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL
por: Raval, Goutham U, et al.
Publicado: (2015)

Localization, quantization and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL
por: Raval, Goutham U, et al.
Publicado: (2015)

Localization, quantization and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL
por: Raval, Goutham U, et al.
Publicado: (2015)

Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia
por: Forlani, Greta, et al.
Publicado: (2021)

Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1
por: Forlani, Greta, et al.
Publicado: (2019)

HTLV-1 HBZ Viral Protein: A Key Player in HTLV-1 Mediated Diseases
por: Baratella, Marco, et al.
Publicado: (2017)

Unveiling the Hidden Treasury: CIITA-Driven MHC Class II Expression in Tumor Cells to Dig up the Relevant Repertoire of Tumor Antigens for Optimal Stimulation of Tumor Specific CD4+ T Helper Cells
por: Forlani, Greta, et al.
Publicado: (2020)

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells
por: Alberio, Tiziana, et al.
Publicado: (2018)

HTLV-1 Infection and Pathogenesis: New Insights from Cellular and Animal Models
por: Forlani, Greta, et al.
Publicado: (2021)

HBZ RNA may promote cell survival against clastogenic damages and thereby contributes to the development of leukemic ATL cells
por: Goicochea, Marco, et al.
Publicado: (2014)

HTLV-1 HBZ Protein Resides Exclusively in the Cytoplasm of Infected Cells in Asymptomatic Carriers and HAM/TSP Patients
por: Forlani, Greta, et al.
Publicado: (2019)

The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy
por: Forlani, Greta, et al.
Publicado: (2023)

Effects of valproate on Tax and HBZ expression in ex vivo cultured ATL cells
por: Belrose, Gildas, et al.
Publicado: (2014)

Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
por: Baratella, Marco, et al.
Publicado: (2017)

Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA
por: Celesti, Fabrizio, et al.
Publicado: (2023)

Targeted zinc-finger repressors to the oncogenic HBZ gene inhibit adult T-cell leukemia (ATL) proliferation
por: Scott, Tristan A, et al.
Publicado: (2023)

The Road to HTLV-1-Induced Leukemia by Following the Subcellular Localization of HTLV-1-Encoded HBZ Protein
por: Accolla, Roberto S.
Publicado: (2022)

Molecular and Cellular Mechanism of Leukemogenesis of ATL: Emergent Evidence of a Significant Role for HBZ in HTLV-1-Induced Pathogenesis
por: Satou, Yorifumi, et al.
Publicado: (2012)

Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model
por: Kuribayashi, Wakako, et al.
Publicado: (2016)

HBZ impedes the Menin function and up-regulates the transcription of the hTERT gene in leukemic cells
por: Borowiak, Malgorzata, et al.
Publicado: (2011)

Tripartite Motif 22 and Class II Transactivator Restriction Factors: Unveiling Their Concerted Action against Retroviruses
por: Forlani, Greta, et al.
Publicado: (2017)

JunD/HBZ enhances HBZ enhances HTLV-1 antisense transcription
por: Peloponese, Jean-Marie, et al.
Publicado: (2011)

ATL internals: working with ATL 8
por: Tavares, Chris
Publicado: (2006)

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
por: Vandermeulen, Charlotte, et al.
Publicado: (2021)

Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication
por: Orlandi, Chiara, et al.
Publicado: (2011)

MHC class II transactivator CIITA inhibits Tax-2-mediated HTLV-2 LTR transactivation and viral replication by binding to, and affecting Tax-2 intracellular localization
por: Orlandi, Chiara, et al.
Publicado: (2011)

The MHC Class II transactivator CIITA inhibits Tax-1-mediated HTLV-1 expression and NF-kB activation
por: Abdallah, Rawan, et al.
Publicado: (2014)

The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators
por: Forlani, Greta, et al.
Publicado: (2013)

CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine
por: Accolla, Roberto S., et al.
Publicado: (2019)

Alternative splicing signatures discriminate ATL cells from untransformed CD4+ counterparts deriving from HTLV-1 infected individuals
por: Thenoz, Morgan, et al.
Publicado: (2014)

Systems biology analysis of the proteomic alterations induced by MPP(+), a Parkinson's disease-related mitochondrial toxin
por: Monti, Chiara, et al.
Publicado: (2015)

Mucosal immune response after the booster dose of the BNT162b2 COVID-19 vaccine
por: Azzi, Lorenzo, et al.
Publicado: (2023)

HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development
por: Maksimova, Victoria, et al.
Publicado: (2023)

ATL internals
por: Rector, Brent, et al.
Publicado: (1999)

ATL internals /
por: Rector, Brent
Publicado: (1999)

Dr. Atl /
por: Luna Arroyo, Antonio
Publicado: (1992)

A Panel of Eight miRNAs Is Deregulated in HTLV-2 Infected PBMCs and BJABGu Cell Line
por: Pilotti, Elisabetta, et al.
Publicado: (2022)

The MHC Class II transactivator CIITA inhibits the persistent activation of NF-kB by Tax-1
por: Forlani, Greta, et al.
Publicado: (2015)

Reply to the Letter to the Editor: “Importance of nasal secretions in the evaluation of mucosal immunity elicited by mRNA BNT162b2 COVID-19 vaccine” by Francavilla B et al.: Lack of a strong oral mucosal immune response: rethinking the route of COVID-19 vaccine boost administration?
por: Azzi, Lorenzo, et al.
Publicado: (2022)

HBZ and its roles in HTLV-1 oncogenesis
por: Zhao, Tiejun, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_3foqiq776teplga1l2bhis2pm9