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Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials

BACKGROUND: There have been several controversies about the correlation between vitamin D and depression. This study aimed to investigate the relationship between vitamin D supplementation and the incidence and prognosis of depression and to analyze the latent effects of subgroups including populati...

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Autores principales: Xie, Fei, Huang, Tongmin, Lou, Dandi, Fu, Rongrong, Ni, Chaoxiong, Hong, Jiaze, Ruan, Lingyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376678/
https://www.ncbi.nlm.nih.gov/pubmed/35979473
http://dx.doi.org/10.3389/fpubh.2022.903547
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author Xie, Fei
Huang, Tongmin
Lou, Dandi
Fu, Rongrong
Ni, Chaoxiong
Hong, Jiaze
Ruan, Lingyan
author_facet Xie, Fei
Huang, Tongmin
Lou, Dandi
Fu, Rongrong
Ni, Chaoxiong
Hong, Jiaze
Ruan, Lingyan
author_sort Xie, Fei
collection PubMed
description BACKGROUND: There have been several controversies about the correlation between vitamin D and depression. This study aimed to investigate the relationship between vitamin D supplementation and the incidence and prognosis of depression and to analyze the latent effects of subgroups including population and supplement strategy. METHODS: A systematic search for articles before July 2021 in databases (PubMed, EMBASE, Web of Science, and the Cochrane Library) was conducted to investigate the effect of vitamin D supplementation on the incidence and prognosis of depression. RESULTS: This meta-analysis included 29 studies with 4,504 participants, indicating that the use of vitamin D was beneficial to a decline in the incidence of depression (SMD: −0.23) and improvement of depression treatment (SMD: −0.92). Subgroup analysis revealed that people with low vitamin D levels (<50 nmol/L) and females could notably benefit from vitamin D in both prevention and treatment of depression. The effects of vitamin D with a daily supplementary dose of >2,800 IU and intervention duration of ≥8 weeks were considered significant in both prevention and treatment analyses. Intervention duration ≤8 weeks was recognized as effective in the treatment group. CONCLUSION: Our results demonstrate that vitamin D has a beneficial impact on both the incidence and the prognosis of depression. Whether suffering from depression or not, individuals with low vitamin D levels, dose >2,800 IU, intervention duration ≥8 weeks, and all females are most likely to benefit from vitamin D supplementation.
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spelling pubmed-93766782022-08-16 Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials Xie, Fei Huang, Tongmin Lou, Dandi Fu, Rongrong Ni, Chaoxiong Hong, Jiaze Ruan, Lingyan Front Public Health Public Health BACKGROUND: There have been several controversies about the correlation between vitamin D and depression. This study aimed to investigate the relationship between vitamin D supplementation and the incidence and prognosis of depression and to analyze the latent effects of subgroups including population and supplement strategy. METHODS: A systematic search for articles before July 2021 in databases (PubMed, EMBASE, Web of Science, and the Cochrane Library) was conducted to investigate the effect of vitamin D supplementation on the incidence and prognosis of depression. RESULTS: This meta-analysis included 29 studies with 4,504 participants, indicating that the use of vitamin D was beneficial to a decline in the incidence of depression (SMD: −0.23) and improvement of depression treatment (SMD: −0.92). Subgroup analysis revealed that people with low vitamin D levels (<50 nmol/L) and females could notably benefit from vitamin D in both prevention and treatment of depression. The effects of vitamin D with a daily supplementary dose of >2,800 IU and intervention duration of ≥8 weeks were considered significant in both prevention and treatment analyses. Intervention duration ≤8 weeks was recognized as effective in the treatment group. CONCLUSION: Our results demonstrate that vitamin D has a beneficial impact on both the incidence and the prognosis of depression. Whether suffering from depression or not, individuals with low vitamin D levels, dose >2,800 IU, intervention duration ≥8 weeks, and all females are most likely to benefit from vitamin D supplementation. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9376678/ /pubmed/35979473 http://dx.doi.org/10.3389/fpubh.2022.903547 Text en Copyright © 2022 Xie, Huang, Lou, Fu, Ni, Hong and Ruan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Xie, Fei
Huang, Tongmin
Lou, Dandi
Fu, Rongrong
Ni, Chaoxiong
Hong, Jiaze
Ruan, Lingyan
Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials
title Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials
title_full Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials
title_fullStr Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials
title_full_unstemmed Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials
title_short Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials
title_sort effect of vitamin d supplementation on the incidence and prognosis of depression: an updated meta-analysis based on randomized controlled trials
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376678/
https://www.ncbi.nlm.nih.gov/pubmed/35979473
http://dx.doi.org/10.3389/fpubh.2022.903547
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