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Fitting the reproduction number from UK coronavirus case data and why it is close to 1
We present a method for rapid calculation of coronavirus growth rates and [Formula: see text]-numbers tailored to publicly available UK data. We assume that the case data comprise a smooth, underlying trend which is differentiable, plus systematic errors and a non-differentiable noise term, and use...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376721/ https://www.ncbi.nlm.nih.gov/pubmed/35965470 http://dx.doi.org/10.1098/rsta.2021.0301 |
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author | Ackland, Graeme J. Ackland, James A. Antonioletti, Mario Wallace, David J. |
author_facet | Ackland, Graeme J. Ackland, James A. Antonioletti, Mario Wallace, David J. |
author_sort | Ackland, Graeme J. |
collection | PubMed |
description | We present a method for rapid calculation of coronavirus growth rates and [Formula: see text]-numbers tailored to publicly available UK data. We assume that the case data comprise a smooth, underlying trend which is differentiable, plus systematic errors and a non-differentiable noise term, and use bespoke data processing to remove systematic errors and noise. The approach is designed to prioritize up-to-date estimates. Our method is validated against published consensus [Formula: see text]-numbers from the UK government and is shown to produce comparable results two weeks earlier. The case-driven approach is combined with weight–shift–scale methods to monitor trends in the epidemic and for medium-term predictions. Using case-fatality ratios, we create a narrative for trends in the UK epidemic: increased infectiousness of the B1.117 (Alpha) variant, and the effectiveness of vaccination in reducing severity of infection. For longer-term future scenarios, we base future [Formula: see text] on insight from localized spread models, which show [Formula: see text] going asymptotically to 1 after a transient, regardless of how large the [Formula: see text] transient is. This accords with short-lived peaks observed in case data. These cannot be explained by a well-mixed model and are suggestive of spread on a localized network. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’. |
format | Online Article Text |
id | pubmed-9376721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-93767212022-08-22 Fitting the reproduction number from UK coronavirus case data and why it is close to 1 Ackland, Graeme J. Ackland, James A. Antonioletti, Mario Wallace, David J. Philos Trans A Math Phys Eng Sci Articles We present a method for rapid calculation of coronavirus growth rates and [Formula: see text]-numbers tailored to publicly available UK data. We assume that the case data comprise a smooth, underlying trend which is differentiable, plus systematic errors and a non-differentiable noise term, and use bespoke data processing to remove systematic errors and noise. The approach is designed to prioritize up-to-date estimates. Our method is validated against published consensus [Formula: see text]-numbers from the UK government and is shown to produce comparable results two weeks earlier. The case-driven approach is combined with weight–shift–scale methods to monitor trends in the epidemic and for medium-term predictions. Using case-fatality ratios, we create a narrative for trends in the UK epidemic: increased infectiousness of the B1.117 (Alpha) variant, and the effectiveness of vaccination in reducing severity of infection. For longer-term future scenarios, we base future [Formula: see text] on insight from localized spread models, which show [Formula: see text] going asymptotically to 1 after a transient, regardless of how large the [Formula: see text] transient is. This accords with short-lived peaks observed in case data. These cannot be explained by a well-mixed model and are suggestive of spread on a localized network. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’. The Royal Society 2022-10-03 2022-08-15 /pmc/articles/PMC9376721/ /pubmed/35965470 http://dx.doi.org/10.1098/rsta.2021.0301 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Ackland, Graeme J. Ackland, James A. Antonioletti, Mario Wallace, David J. Fitting the reproduction number from UK coronavirus case data and why it is close to 1 |
title | Fitting the reproduction number from UK coronavirus case data and why it is close to 1 |
title_full | Fitting the reproduction number from UK coronavirus case data and why it is close to 1 |
title_fullStr | Fitting the reproduction number from UK coronavirus case data and why it is close to 1 |
title_full_unstemmed | Fitting the reproduction number from UK coronavirus case data and why it is close to 1 |
title_short | Fitting the reproduction number from UK coronavirus case data and why it is close to 1 |
title_sort | fitting the reproduction number from uk coronavirus case data and why it is close to 1 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376721/ https://www.ncbi.nlm.nih.gov/pubmed/35965470 http://dx.doi.org/10.1098/rsta.2021.0301 |
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