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Fitting the reproduction number from UK coronavirus case data and why it is close to 1

We present a method for rapid calculation of coronavirus growth rates and [Formula: see text]-numbers tailored to publicly available UK data. We assume that the case data comprise a smooth, underlying trend which is differentiable, plus systematic errors and a non-differentiable noise term, and use...

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Detalles Bibliográficos
Autores principales: Ackland, Graeme J., Ackland, James A., Antonioletti, Mario, Wallace, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376721/
https://www.ncbi.nlm.nih.gov/pubmed/35965470
http://dx.doi.org/10.1098/rsta.2021.0301
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author Ackland, Graeme J.
Ackland, James A.
Antonioletti, Mario
Wallace, David J.
author_facet Ackland, Graeme J.
Ackland, James A.
Antonioletti, Mario
Wallace, David J.
author_sort Ackland, Graeme J.
collection PubMed
description We present a method for rapid calculation of coronavirus growth rates and [Formula: see text]-numbers tailored to publicly available UK data. We assume that the case data comprise a smooth, underlying trend which is differentiable, plus systematic errors and a non-differentiable noise term, and use bespoke data processing to remove systematic errors and noise. The approach is designed to prioritize up-to-date estimates. Our method is validated against published consensus [Formula: see text]-numbers from the UK government and is shown to produce comparable results two weeks earlier. The case-driven approach is combined with weight–shift–scale methods to monitor trends in the epidemic and for medium-term predictions. Using case-fatality ratios, we create a narrative for trends in the UK epidemic: increased infectiousness of the B1.117 (Alpha) variant, and the effectiveness of vaccination in reducing severity of infection. For longer-term future scenarios, we base future [Formula: see text] on insight from localized spread models, which show [Formula: see text] going asymptotically to 1 after a transient, regardless of how large the [Formula: see text] transient is. This accords with short-lived peaks observed in case data. These cannot be explained by a well-mixed model and are suggestive of spread on a localized network. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’.
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spelling pubmed-93767212022-08-22 Fitting the reproduction number from UK coronavirus case data and why it is close to 1 Ackland, Graeme J. Ackland, James A. Antonioletti, Mario Wallace, David J. Philos Trans A Math Phys Eng Sci Articles We present a method for rapid calculation of coronavirus growth rates and [Formula: see text]-numbers tailored to publicly available UK data. We assume that the case data comprise a smooth, underlying trend which is differentiable, plus systematic errors and a non-differentiable noise term, and use bespoke data processing to remove systematic errors and noise. The approach is designed to prioritize up-to-date estimates. Our method is validated against published consensus [Formula: see text]-numbers from the UK government and is shown to produce comparable results two weeks earlier. The case-driven approach is combined with weight–shift–scale methods to monitor trends in the epidemic and for medium-term predictions. Using case-fatality ratios, we create a narrative for trends in the UK epidemic: increased infectiousness of the B1.117 (Alpha) variant, and the effectiveness of vaccination in reducing severity of infection. For longer-term future scenarios, we base future [Formula: see text] on insight from localized spread models, which show [Formula: see text] going asymptotically to 1 after a transient, regardless of how large the [Formula: see text] transient is. This accords with short-lived peaks observed in case data. These cannot be explained by a well-mixed model and are suggestive of spread on a localized network. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’. The Royal Society 2022-10-03 2022-08-15 /pmc/articles/PMC9376721/ /pubmed/35965470 http://dx.doi.org/10.1098/rsta.2021.0301 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Ackland, Graeme J.
Ackland, James A.
Antonioletti, Mario
Wallace, David J.
Fitting the reproduction number from UK coronavirus case data and why it is close to 1
title Fitting the reproduction number from UK coronavirus case data and why it is close to 1
title_full Fitting the reproduction number from UK coronavirus case data and why it is close to 1
title_fullStr Fitting the reproduction number from UK coronavirus case data and why it is close to 1
title_full_unstemmed Fitting the reproduction number from UK coronavirus case data and why it is close to 1
title_short Fitting the reproduction number from UK coronavirus case data and why it is close to 1
title_sort fitting the reproduction number from uk coronavirus case data and why it is close to 1
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376721/
https://www.ncbi.nlm.nih.gov/pubmed/35965470
http://dx.doi.org/10.1098/rsta.2021.0301
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